Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 4/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 4/20 | 0.38 |
| ▸ | SKP1 | P63208 | 4/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 4/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951404 | 0.84 | CKS1B (0.54) | CKS1BSKP1SKP2 | |
| SCHEMBL4438731 | 0.81 | ALDH1A1 (0.44) | ALDH1A1CSNK1DMAPK14LMNATSHR | |
| SCHEMBL2967476 | 0.81 | CSNK1D (0.60) | CSNK1DMAPK14LMNAMAPK11 | |
| SCHEMBL19748343 | 0.72 | PANK3 (0.59) | — | |
| SCHEMBL5238054 | 0.70 | HTR1A (0.57) | ALDH1A1LMNATSHRSLC6A7KDM4E | |
| SCHEMBL4443140 | 0.68 | KDM4E (0.41) | ALDH1A1CSNK1DMAPK14LMNASMO | |
| SCHEMBL20140586 | 0.68 | PARP1 (0.44) | ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL3442387 | 0.68 | ALDH1A1 (0.56) | ALDH1A1LMNATSHRSLC6A7KDM4E | |
| SCHEMBL1686083 | 0.68 | MET (0.45) | ALDH1A1LMNATSHRSLC6A7KDM4E | |
| SCHEMBL4443105 | 0.68 | KDM4E (0.40) | ALDH1A1CSNK1DMAPK14LMNASMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121630-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008098892-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | disclosed |