Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 8/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19681457 | 0.84 | TDP1 (0.47) | TDP1POLBL3MBTL1MAPTHTT | |
| SCHEMBL27381621 | 0.83 | TDP1 (0.62) | TDP1POLBL3MBTL1MAPTHTT | |
| SCHEMBL901472 | 0.82 | TDP1 (0.72) | TDP1POLBL3MBTL1MAPTHTT | |
| SCHEMBL4675294 | 0.81 | HTT (0.44) | TDP1POLBL3MBTL1MAPTHTT | |
| SCHEMBL20894921 | 0.80 | HDAC4 (0.50) | TDP1POLBL3MBTL1MAPTHTT | |
| SCHEMBL8795897 | 0.80 | TDP1 (0.58) | TDP1POLBL3MBTL1MAPTHTT | |
| SCHEMBL8610246 | 0.80 | TDP1 (0.69) | TDP1POLBL3MBTL1MAPTHTT | |
| Sumiki'S Acid SCHEMBL29706392 | 0.80 | TDP1 (1.00) | TDP1POLBL3MBTL1MAPTHTT | |
| Sumiki'S Acid SCHEMBL50822 | 0.80 | TDP1 (1.00) | TDP1POLBL3MBTL1MAPTHTT | |
| SCHEMBL18554594 | 0.78 | TDP1 (0.67) | TDP1POLBL3MBTL1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4247810-A1 | N-[(1,3-BENZOXAZOL-2-YL)-HETEROCYCLE]AMIDE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2023-09-27 | — | — | EP | disclosed |
| CN-116529246-A | N- [ (1, 3-benzoxazol-2-yl) -heterocycle ] amide derivatives for the treatment and prevention of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-116390920-A | Aromatic spirocyclic amide derivatives for the treatment and prevention of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2023-07-04 | — | — | CN | disclosed |
| WO-2022106680-A1 | N-[(1,3-BENZOXAZOL-2-YL)-HETEROCYCLE]AMIDE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2022-05-27 | — | — | WO | disclosed |
| US-10392358-B2 | Oxidation chemistry on furan aldehydes | MICROMIDAS, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-10392358-B2 | Oxidation chemistry on furan aldehydes | MICROMIDAS, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| CN-108558848-A | A kind of cycloalkane thiophthene derivative and preparation method thereof and medical usage | 华东师范大学 | 2018-09-21 | — | — | CN | disclosed |
| US-20180265488-A1 | OXIDATION CHEMISTRY ON FURAN ALDEHYDES | MICROMIDAS, INC. (US) | 2018-09-20 | — | — | US | disclosed |
| CN-108349920-A | OXIDATION CHEMISTRY ON FURAN ALDEHYDES | 微麦德斯公司 | 2018-07-31 | — | — | CN | disclosed |
| WO-2017049211-A1 | OXIDATION CHEMISTRY ON FURAN ALDEHYDES | MICROMIDAS, INC. (US) | 2017-03-23 | — | — | WO | disclosed |
| US-20080027060-A1 | DIPEPTIDE NITRILES | ALTMANN EVA | 2008-01-31 | — | — | US | disclosed |
| US-20060235220-A1 | Dipeptide nitriles | MISSBACH MARTIN | 2006-10-19 | — | — | US | disclosed |
| CN-1747936-A | Substituted azole derivatives as therapeutic agents | TRANSTECH PHARMA INC (US) | 2006-03-15 | — | — | CN | disclosed |
| US-20040110806-A1 | Dipeptide derivatives | ALTMANN EVA (CH) | 2004-06-10 | — | — | US | disclosed |
| US-20040029814-A1 | Dipeptide nitriles | ALTMANN EVA (CH) | 2004-02-12 | — | — | US | disclosed |
| US-6353017-B1 | INHIBITORS OF CATHESPINS USING DIPEPTIDE NITRILES AS ANTIINFLAMMATORY AGENTS AND ANTIARTHRITIC AGENTS | NOVARTIS AG (CH) | 2002-03-05 | — | — | US | disclosed |
| EP-1028942-A2 | DIPEPTIDE NITRILES | Novartis AG (CH) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024460-A2 | DIPEPTIDE NITRILES | NOVARTIS AG (CH) | 1999-05-20 | — | — | WO | disclosed |
| US-5849693-A | Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein IIb/IIIa | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| US-5773411-A | CARDIOVASCULAR DISORDERS AND BRAIN DISORDERS AND COAGULANTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392358-B2 | Oxidation chemistry on furan aldehydes | AOX1, ALOX5, CBR1 | TDP1 2488/4885POLB 2337/4885L3MBTL1 2764/4885 |
| US-20040110806-A1 | Dipeptide derivatives | CTSL, CTSZ, CTSS | TDP1 2648/4885POLB 3564/4885L3MBTL1 432/4885 |
| US-20040029814-A1 | Dipeptide nitriles | NOS1, CTSL, CTSS | TDP1 2327/4885POLB 3338/4885L3MBTL1 965/4885 |
| US-20060235220-A1 | Dipeptide nitriles | CTSL, CTSS, CTSB | TDP1 2871/4885POLB 3387/4885L3MBTL1 329/4885 |
| US-20180265488-A1 | OXIDATION CHEMISTRY ON FURAN ALDEHYDES | AOX1, ALOX5, CBR1 | TDP1 2488/4885POLB 2337/4885L3MBTL1 2764/4885 |
| US-20080027060-A1 | DIPEPTIDE NITRILES | CTSL, CTSS, CTSB | TDP1 2871/4885POLB 3387/4885L3MBTL1 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.