SCHEMBL4445832

SCHEMBL4445832

Nc1ccccc1COC(=O)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.61
TDP1 Q9NUW8 2/20 0.59
KMT2A Q03164 2/20 0.59
SLC6A2 P23975 1/20 0.59
SLC6A3 Q01959 1/20 0.59
LMNA P02545 3/20 0.50
MAPK1 P28482 2/20 0.50
HIF1A Q16665 1/20 0.50
NPSR1 Q6W5P4 1/20 0.49
ALDH1A1 P00352 3/20 0.49
L3MBTL1 Q9Y468 2/20 0.48
KDM4E B2RXH2 1/20 0.47
GAA P10253 1/20 0.47
TSHR P16473 1/20 0.46
F2 P00734 1/20 0.45
RAB9A P51151 3/20 0.45
NPC1 O15118 1/20 0.45
MAPT P10636 3/20 0.44
POLB P06746 1/20 0.44
PKM P14618 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5085480 0.87 PPARG (0.71) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL31253930 0.83 ALDH1A1 (0.42) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL31253931 0.83 ALDH1A1 (0.42) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL27746393 0.83 LMNA (0.65) TDP1KMT2ALMNAMAPK1ALDH1A1
SCHEMBL3674585 0.82 PPARG (0.61) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL7349537 0.82 RAB9A (0.44) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL4577944 0.81 PPARG (0.65) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL28768397 0.81 MAPT (0.53) PPARGTDP1KMT2ASLC6A2SLC6A3
SCHEMBL1560611 0.81 ALDH1A1 (0.43) PPARGTDP1KMT2AMAPK1HIF1A
SCHEMBL6243415 0.80 PPARG (0.63) PPARGTDP1KMT2ASLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2035459-B1 COVALENT CONJUGATES OF COTTON AND SUBSTITUTES (VISCOSE, MODAL COTTON) WITH BIOACTIVE SUBSTANCES HAVING ANTISEPTIC, SANITIZING, ACARICIDAL AND INSECT REPELLENT ACTIVITY, AND A METHOD FOR OBTAINING THEM FRANZONI FILATI S P A (IT) 2009-12-16 EP disclosed
EP-2035459-A2 COVALENT CONJUGATES OF COTTON AND SUBSTITUTES (VISCOSE, MODAL COTTON) WITH BIOACTIVE SUBSTANCES HAVING ANTISEPTIC, SANITIZING, ACARICIDAL AND INSECT REPELLENT ACTIVITY, AND A METHOD FOR OBTAINING THEM Franzoni Filati S.p.A. (IT) 2009-03-18 EP disclosed
WO-2007135548-A2 COVALENT CONJUGATES OF COTTON AND SUBSTITUTES (VISCOSE, MODAL COTTON) WITH BIOACTIVE SUBSTANCES HAVING ANTISEPTIC, SANITIZING, ACARICIDAL AND INSECT REPELLENT ACTIVITY, AND A METHOD FOR OBTAINING THEM FRANZONI FILATI S.P.A. (IT) 2007-11-29 WO disclosed
US-20050059735-A1 Cyclic amino acid derivatives useful as pharmaceutical agents BRYANS JUSTIN STEPHEN (GB) 2005-03-17 US disclosed
US-20030216469-A1 Cyclic amino acid derivatives useful as pharmaceutical agents BRYANS JUSTIN STEPHEN (GB) 2003-11-20 US disclosed
EP-1284960-A1 CYCLIC AMINO ACID DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2003-02-26 EP disclosed
WO-2001090052-A1 CYCLIC AMINO ACID DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS WARNER-LAMBERT COMPANY (US) 2001-11-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050059735-A1 Cyclic amino acid derivatives useful as pharmaceutical agents QPCT, ARGLU1, PNISR PPARG 3773/4885TDP1 2782/4885KMT2A 3098/4885
US-20030216469-A1 Cyclic amino acid derivatives useful as pharmaceutical agents QPCT, ARGLU1, QPCTL PPARG 4065/4885TDP1 2516/4885KMT2A 3288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.