SCHEMBL4448496

SCHEMBL4448496

Clc1cc(Cl)c(-c2c(Cl)cccc2Cl)c(Cl)c1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.48
TSHR P16473 5/20 0.44
HPGD P15428 3/20 0.44
HSD17B10 Q99714 3/20 0.44
MAPK1 P28482 1/20 0.44
CASP1 P29466 1/20 0.42
AHR P35869 6/20 0.41
ALDH1A1 P00352 2/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2A6 P11509 1/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
LMNA P02545 1/20 0.36
PNMT P11086 1/20 0.34
NR4A2 P43354 1/20 0.34
HSP90AA1 P07900 2/20 0.34
GRIA1 P42261 1/20 0.33
CACNG8 Q8WXS5 1/20 0.33
AKR1B1 P15121 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4453792 0.84 TSHR (0.46) CYP3A4TSHRHPGDHSD17B10MAPK1
SCHEMBL3889367 0.84 CYP3A4 (0.67) CYP3A4TSHRHPGDHSD17B10MAPK1
SCHEMBL30621942 0.84 CYP3A4 (0.67) CYP3A4TSHRHPGDHSD17B10MAPK1
SCHEMBL4459037 0.82 CYP3A4 (0.50) CYP3A4TSHRHPGDHSD17B10MAPK1
SCHEMBL30621937 0.82 CYP3A4 (0.50) CYP3A4TSHRHPGDHSD17B10MAPK1
SCHEMBL4452922 0.81 ALDH1A1 (0.61) CYP3A4TSHRHPGDHSD17B10MAPK1
SCHEMBL4450215 0.79 CYP3A4 (0.42) CYP3A4TSHRHPGDHSD17B10MAPK1
SCHEMBL4452908 0.78 CYP1A2 (0.45) CYP3A4TSHRALDH1A1CYP1A2CYP2A6
SCHEMBL4452879 0.78 TSHR (0.50) CYP3A4TSHRHPGDHSD17B10MAPK1
SCHEMBL4459306 0.78 CYP3A4 (0.59) CYP3A4TSHRHPGDHSD17B10MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3881907-A1 METHOD FOR DECHLORINATION OF ONE OR MORE AROMATIC ORGANOCHLORINE COMPOUND(S) CONTAINED IN AN OIL OR FORMING SAID OIL - ASSOCIATED ELECTRICAL/ELECTRONIC DEVICE AND INSTALLATION Université de Lille (FR) 2021-09-22 EP claimed
US-20230330725-A1 VOLATILIZATION AND OXIDATION OF ORGANIC WASTE NATIONAL BANK OF CANADA (CA) 2023-10-19 US disclosed
CN-113445835-B Integrated controller with sensor for latch housing 麦格纳覆盖件有限公司 2023-05-30 CN disclosed
CN-112771317-B Condensate pump assembly 艾斯本泵业有限公司 2022-10-14 CN disclosed
EP-3881907-A1 METHOD FOR DECHLORINATION OF ONE OR MORE AROMATIC ORGANOCHLORINE COMPOUND(S) CONTAINED IN AN OIL OR FORMING SAID OIL - ASSOCIATED ELECTRICAL/ELECTRONIC DEVICE AND INSTALLATION Université de Lille (FR) 2021-09-22 EP disclosed
US-20090269857-A1 Instruments for detecting low-molecular weight substance FUJIKURA KASEI CO., LTD. (JP) 2009-10-29 US disclosed
EP-1489420-A1 INSTRUMENTS FOR DETECTING LOW-MOLECULAR WEIGHT SUBSTANCE Enbiotec Laboratories Co., Ltd. (JP) 2004-12-22 EP disclosed