Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | SHBG | P04278 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1878465 | 0.86 | KDM4E (0.47) | NPC1RAB9ALMNASMN1; SMN2GAA | |
| SCHEMBL3346345 | 0.76 | ESR1 (0.64) | ESR1SHBGESR2CA2FNTA | |
| SCHEMBL7533339 | 0.75 | CYP19A1 (0.69) | ESR1SHBGESR2CA2FNTA | |
| SCHEMBL10582732 | 0.74 | MMP2 (0.44) | NPC1RAB9ASMN1; SMN2GAAMAPT | |
| SCHEMBL9737659 | 0.74 | LIG1 (0.56) | ESR1ESR2CA2RAB9ALMNA | |
| SCHEMBL4175858 | 0.73 | KDM4E (0.56) | NPC1RAB9ALMNASMN1; SMN2GAA | |
| SCHEMBL14677779 | 0.73 | PTPN1 (0.52) | GAAMAPTMMP2ALDH1A1HIF1A | |
| SCHEMBL9632452 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2GAAMAPTMMP2ALDH1A1 | |
| SCHEMBL10954405 | 0.72 | G6PD (0.52) | LMNASMN1; SMN2MAPTMMP2MEN1 | |
| Hydrochloric Acid SCHEMBL9151636 | 0.72 | KDM4E (0.54) | NPC1RAB9ALMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124555-A1 | USE OF HISTOGRANIN AND HISTOGRANIN-LIKE COMPOUNDS AS INHIBITORS OF P2X7 RECEPTOR FUNCTION AND AS ANTI-ARTHRITIC AGENTS | BERNATCHEZ-LEMAIRE IRMA | 2009-05-14 | — | — | US | disclosed |
| WO-2007025366-A1 | USE OF HISTOGRANIN AND HISTOGRANIN-LIKE COMPOUNDS AS INHIBITORS OF P2X7 RECEPTOR FUNCTION AND AS ANTI-ARTHRITIC AGENTS | BERNATCHEZ-LEMAIRE IRMA (CA) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124555-A1 | USE OF HISTOGRANIN AND HISTOGRANIN-LIKE COMPOUNDS AS INHIBITORS OF P2X7 RECEPTOR FUNCTION AND AS ANTI-ARTHRITIC AGENTS | P2RX5, P2RX3, P2RX2 | ESR1 3152/4885SHBG 2156/4885ESR2 3078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.