SCHEMBL4460425

SCHEMBL4460425

CC1(C)CC2(CC(C)(C)c3c(Cl)cc(O)cc32)c2cc(O)cc(Cl)c21

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.38
HSD17B10 Q99714 2/20 0.38
HPGD P15428 1/20 0.38
CRHBP P24387 1/20 0.38
CRHR2 Q13324 1/20 0.38
FTO Q9C0B1 1/20 0.34
CHRM1 P11229 1/20 0.31
ALOX15 P16050 1/20 0.31
MAOA P21397 1/20 0.31
TBXA2R P21731 1/20 0.31
ADRA1A P35348 1/20 0.31
HTR2B P41595 1/20 0.31
ESR1 P03372 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8015643 0.85 CYP3A4 (0.38) CYP3A4HSD17B10HPGDCRHBPCRHR2
SCHEMBL217715 0.81 CYP3A4 (0.35) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL4469324 0.77 CYP3A4 (0.42) CYP3A4FTO
SCHEMBL8859642 0.73 CYP3A4 (0.34) CYP3A4HSD17B10HPGDCRHBPCRHR2
SCHEMBL11650120 0.72 CYP3A4 (0.37) CYP3A4HSD17B10HPGDCRHBPCRHR2
SCHEMBL3919468 0.71 TP53 (0.31)
SCHEMBL4460410 0.69 FTO (0.51) CYP3A4HSD17B10HPGDFTO
SCHEMBL8014576 0.69 FTO (0.51) CYP3A4HSD17B10HPGDFTO
SCHEMBL169731 0.68 OPRM1 (0.39) CYP3A4HSD17B10FTOALOX15ESR1
SCHEMBL29914192 0.68 OPRM1 (0.39) CYP3A4HSD17B10FTOALOX15ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7582355-B2 Optical unit using plastic lenses FUJIFILM CORPORATION (JP) 2009-09-01 US disclosed
US-20060046065-A1 Optical unit using plastic lenses FUJI PHOTO FILM CO., LTD. 2006-03-02 US disclosed
US-6028161-A EXCELLENT TRANSPARENCY, HEAT RESISTANCE AND MECHANICAL PROPERTIES AND A LOW BIREFRINGENCE, MELT FLUIDITY AND MOLDABILITY; AN OPTICAL DISK, LENS AND AN OPTICAL FIBER MITSUI CHEMICALS, INC. (JP) 2000-02-22 US disclosed
EP-0926180-A2 A polycarbonate copolymer and applications thereof Mitsui Chemicals, Inc. (JP) 1999-06-30 EP disclosed