SCHEMBL4469324

SCHEMBL4469324

COc1cc(O)cc2c1C(C)(C)CC21CC(C)(C)c2c(OC)cc(O)cc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.42
MAPT P10636 2/20 0.42
PTGS2 P35354 6/20 0.38
ALOX5 P09917 5/20 0.38
MAOB P27338 1/20 0.36
FTO Q9C0B1 1/20 0.33
NPC1 O15118 2/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32
APEX1 P27695 1/20 0.32
HTT P42858 1/20 0.32
KMT2A Q03164 1/20 0.32
TDP1 Q9NUW8 2/20 0.31
MAPK1 P28482 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
USP2 O75604 1/20 0.31
CYP1A1 P04798 1/20 0.31
PTGS1 P23219 1/20 0.31
ERN1 O75460 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4460425 0.77 CYP3A4 (0.38) CYP3A4FTO
SCHEMBL217715 0.77 CYP3A4 (0.35) CYP3A4MEN1KMT2AALDH1A1
SCHEMBL4464547 0.70 FTO (0.39) CYP3A4MAPTPTGS2MAOBFTO
SCHEMBL11136773 0.70 CA12 (0.41) CYP3A4MAPTFTOKDM4EHTT
SCHEMBL12110373 0.69 FTO (0.38) MAPTMAOBFTOHTTTP53
SCHEMBL13979784 0.69 FTO (0.38) MAPTPTGS2MAOBFTOTP53
SCHEMBL10001255 0.67 FTO (0.40) CYP3A4MAPTMAOBFTOMAPK1
SCHEMBL3919468 0.67 TP53 (0.31) TP53
SCHEMBL11209387 0.67 FTO (0.31) FTO
SCHEMBL11213073 0.66 LMNA (0.50) CYP3A4MAPTMEN1POLBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7582355-B2 Optical unit using plastic lenses FUJIFILM CORPORATION (JP) 2009-09-01 US disclosed
US-20060046065-A1 Optical unit using plastic lenses FUJI PHOTO FILM CO., LTD. 2006-03-02 US disclosed
US-6028161-A EXCELLENT TRANSPARENCY, HEAT RESISTANCE AND MECHANICAL PROPERTIES AND A LOW BIREFRINGENCE, MELT FLUIDITY AND MOLDABILITY; AN OPTICAL DISK, LENS AND AN OPTICAL FIBER MITSUI CHEMICALS, INC. (JP) 2000-02-22 US disclosed
EP-0926180-A2 A polycarbonate copolymer and applications thereof Mitsui Chemicals, Inc. (JP) 1999-06-30 EP disclosed