SCHEMBL446213

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL444342	0.88	LMNA (0.57)	ALDH1A1LMNACA2KMT2AMEN1
	SCHEMBL447265	0.87	ALDH1A1 (0.43)	ALDH1A1LMNACA2KMT2AMEN1
	SCHEMBL443448	0.86	GRM2 (0.40)	ALDH1A1LMNACA2KMT2AMEN1
	SCHEMBL446371	0.84	ALOX5 (0.53)	ALDH1A1LMNAKMT2AMEN1PTPN1
	SCHEMBL448085	0.83	ALDH1A1 (0.52)	ALDH1A1LMNACA2KMT2AMEN1
	SCHEMBL445377	0.83	PTGES (0.51)	ALDH1A1LMNAKMT2AMEN1
	SCHEMBL444612	0.81	CA2 (0.46)	ALDH1A1LMNACA2KMT2APTPN1
	SCHEMBL446132	0.79	LTB4R2 (0.45)	ALDH1A1LMNACA2KMT2ASMN1; SMN2
	SCHEMBL446829	0.78	GRM2 (0.38)	CA2GRM2PPARGPPARDPPARA
	SCHEMBL445234	0.78	PTGES (0.48)	CA2KMT2AMEN1L3MBTL1MEP1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.