Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.50 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TYR | P14679 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740749 | 1.00 | ALDH1A1 (0.50) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL11160785 | 0.92 | ALDH1A1 (0.54) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL24053470 | 0.91 | ALOX15 (0.41) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL23633278 | 0.85 | ALDH1A1 (0.54) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL29569404 | 0.84 | RXRA (0.35) | ALDH1A1KDM4ECYP1A2MAPTTP53 | |
| SCHEMBL196263 | 0.84 | RXRA (0.35) | ALDH1A1KDM4ECYP1A2MAPTTP53 | |
| SCHEMBL11163156 | 0.80 | ALOX15 (0.41) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL3414363 | 0.79 | ALDH1A1 (0.40) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL3417210 | 0.78 | ALDH1A1 (0.41) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL218400 | 0.77 | ALDH1A1 (0.37) | ALDH1A1ALOX15KDM4ECYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213011-A1 | 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF | ZHEJIANG UNIVERSITY (CN) | 2022-07-07 | — | — | US | disclosed |
| US-11377457-B2 | 3,3,3',3'-tetramethyl-1,1'-spirobiindane-based monophosphine ligand, intermediates thereof, preparation method and use of the same | ZHEJIANG UNIVERSITY (CN) | 2022-07-05 | — | — | US | disclosed |
| US-20210070789-A1 | 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED MONOPHOSPHINE LIGAND, INTERMEDATES TEHREOF, PREPARATION METHOD AND USE OF THE SAME | ZHEJIANG UNIVERSITY (CN) | 2021-03-11 | — | — | US | disclosed |
| CN-108659046-B | Monophosphine ligand based on tetramethyl spiroindane skeleton, intermediate thereof, preparation method and application | 浙江大学 | 2020-04-10 | — | — | CN | disclosed |
| WO-2019213987-A1 | MONOPHOSPHINE LIGAND BASED ON TETRAMETHYL SPIROBIINDANE SKELETON AND INTERMEDIATE THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江大学 (CN) | 2019-11-14 | — | — | WO | disclosed |
| US-7582355-B2 | Optical unit using plastic lenses | FUJIFILM CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-20060046065-A1 | Optical unit using plastic lenses | FUJI PHOTO FILM CO., LTD. | 2006-03-02 | — | — | US | disclosed |
| US-6028161-A | EXCELLENT TRANSPARENCY, HEAT RESISTANCE AND MECHANICAL PROPERTIES AND A LOW BIREFRINGENCE, MELT FLUIDITY AND MOLDABILITY; AN OPTICAL DISK, LENS AND AN OPTICAL FIBER | MITSUI CHEMICALS, INC. (JP) | 2000-02-22 | — | — | US | disclosed |
| EP-0926180-A2 | A polycarbonate copolymer and applications thereof | Mitsui Chemicals, Inc. (JP) | 1999-06-30 | — | — | EP | disclosed |
| EP-0307951-B1 | Light-sensitive resin composition | FUJI PHOTO FILM CO LTD (JP) | 1994-03-02 | — | — | EP | disclosed |
| US-4883739-A | PHOTORESISTS | FUJI PHOTO FILM CO., LTD. (JP) | 1989-11-28 | — | — | US | disclosed |
| EP-0307951-A2 | Light-sensitive resin composition | FUJI PHOTO FILM CO., LTD. (JP) | 1989-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11377457-B2 | 3,3,3',3'-tetramethyl-1,1'-spirobiindane-based monophosphine ligand, intermediates thereof, preparation method and use of the same | PHOSPHO1, TPI1, TPR | ALDH1A1 219/4885ALOX15 2430/4885SMN1; SMN2 4445/4885 |
| US-20220213011-A1 | 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF | TALDO1, REN, PKD1 | ALDH1A1 123/4885ALOX15 994/4885SMN1; SMN2 4121/4885 |
| US-20210070789-A1 | 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED MONOPHOSPHINE LIGAND, INTERMEDATES TEHREOF, PREPARATION METHOD AND USE OF THE SAME | PHOSPHO1, TPI1, TALDO1 | ALDH1A1 477/4885ALOX15 3772/4885SMN1; SMN2 4505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.