Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 4/20 | 0.41 |
| ▸ | CASP6 | P55212 | 4/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 4/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837058 | 0.81 | SMN1; SMN2 (0.47) | CASP3CASP6CASP8FFAR1MEN1 | |
| SCHEMBL28291329 | 0.71 | KDM4E (0.53) | CTSBGRM2KDM4EPOLBHPGD | |
| SCHEMBL23112167 | 0.70 | ALDH1A1 (0.49) | GRM2KDM4EMEN1KMT2AHPGD | |
| SCHEMBL9937004 | 0.69 | CASP3 (0.43) | CTSBCASP3CASP6CASP8 | |
| SCHEMBL16857265 | 0.68 | CES2 (0.49) | MEN1POLBKMT2A | |
| SCHEMBL851513 | 0.68 | CTSK (0.45) | CTSBCASP3FFAR1MEN1KMT2A | |
| SCHEMBL15763907 | 0.68 | CES2 (0.44) | CTSBGRM2KMT2AHPGD | |
| SCHEMBL15684654 | 0.68 | GRM2 (0.45) | GRM2FFAR1 | |
| SCHEMBL13506327 | 0.67 | LMNA (0.56) | GRM2KDM4EKMT2A | |
| SCHEMBL17897035 | 0.67 | L3MBTL1 (0.54) | FFAR1KDM4EPTGER2POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |