Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438197 | 0.92 | ESR2 (0.41) | ESR2PSMB5LMNASMN1; SMN2MCOLN3 | |
| SCHEMBL448143 | 0.79 | CA2 (0.43) | LMNACYP2A6CA1CA2ALDH1A1 | |
| SCHEMBL431299 | 0.78 | MGLL (0.48) | ESR2SMN1; SMN2ALOX5MGLLCA1 | |
| SCHEMBL30255125 | 0.77 | PDCD1 (0.44) | ESR2SMN1; SMN2BACE1MGLLCYP2A6 | |
| SCHEMBL8986922 | 0.75 | ESR2 (0.52) | ESR2PSMB5LMNASMN1; SMN2MCOLN3 | |
| SCHEMBL24665564 | 0.74 | MGLL (0.48) | ESR2LMNASMN1; SMN2BACE1ALOX5 | |
| SCHEMBL9423370 | 0.74 | PSMB5 (0.49) | ESR2PSMB5LMNASMN1; SMN2MCOLN3 | |
| SCHEMBL19464511 | 0.73 | HDAC7 (0.49) | ESR2PSMB5LMNAMETAP2HDAC7 | |
| Water SCHEMBL19349803 | 0.72 | PSMB5 (0.47) | ESR2PSMB5LMNASMN1; SMN2MCOLN3 | |
| SCHEMBL2528210 | 0.71 | BACE1 (0.54) | ESR2PSMB5METAP2HDAC7BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115490607-A | C 2 Synthesis method of-symmetrical chiral aryl iodide catalyst | 南通大学 | 2022-12-20 | — | — | CN | disclosed |
| US-8536351-B2 | 2-aryl-5-heterocyclyl-cyclohexane-1,3,dione compounds and their use as herbicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-09-17 | — | — | US | disclosed |
| EP-2429979-A1 | NOVEL HERBICIDES | Syngenta Limited (GB) | 2012-03-21 | — | — | EP | disclosed |
| US-20120065066-A1 | NOVEL HERBICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2012-03-15 | — | — | US | disclosed |
| US-8084649-B2 | Herbicides | SYNGENTA CROP PROTECTION, INC. (US) | 2011-12-27 | — | — | US | disclosed |
| EP-2134699-B1 | 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3-DIONE COMPOUNDS AND THEIR USE AS HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010133232-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2010-11-25 | — | — | WO | disclosed |
| US-20100173774-A1 | NOVEL HERBICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| US-20100113270-A1 | 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3,DIONE COMPOUNDS AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| EP-2134699-A1 | 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3-DIONE COMPOUNDS AND THEIR USE AS HERBICIDES | Syngeta Participations AG (CH) | 2009-12-23 | — | — | EP | disclosed |
| EP-2121584-A2 | NOVEL HERBICIDES | Syngeta Participations AG (CH) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008110307-A1 | 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3-DIONE COMPOUNDS AND THEIR USE AS HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110308-A2 | NOVEL HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065066-A1 | NOVEL HERBICIDES | DDT, CYP4X1, CYP1B1 | ESR2 1787/4885PSMB5 2872/4885LMNA 4657/4885 |
| US-20100113270-A1 | 2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3,DIONE COMPOUNDS AND THEIR USE AS HERBICIDES | C3AR1, C5, C9 | ESR2 517/4885PSMB5 1083/4885LMNA 1709/4885 |
| US-20100173774-A1 | NOVEL HERBICIDES | DDT, HDHD5, HPD | ESR2 1428/4885PSMB5 1811/4885LMNA 4588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.