Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | GNRHR | P30968 | 9/20 | 0.42 |
| ▸ | WNT1 | P04628 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474514 | 0.82 | GNRHR (0.47) | HTR1AHTR1DHTR1BHTR6GNRHR | |
| SCHEMBL13324655 | 0.80 | HDAC6 (0.50) | HTR1AGNRHRTACR2HRH2OPRM1 | |
| SCHEMBL4468341 | 0.79 | PRKCI (0.47) | AURKAHTR1AHTR1DHTR1BHTR6 | |
| SCHEMBL3274724 | 0.75 | GNRHR (0.70) | GNRHR | |
| SCHEMBL21705380 | 0.66 | AURKA (0.65) | AURKAPRMT5HDAC6 | |
| SCHEMBL31063805 | 0.66 | AURKA (0.65) | AURKAPRMT5HDAC6 | |
| SCHEMBL4558382 | 0.66 | NCF1 (0.49) | HTR6ADRB2NCF1 | |
| SCHEMBL4470282 | 0.64 | HDAC6 (0.51) | AURKAHDAC6 | |
| SCHEMBL270283 | 0.64 | ADRB1 (0.62) | HTR1AHTR6HTR3AADRB2NCF1 | |
| SCHEMBL6862878 | 0.64 | HTR6 (0.51) | HTR1AHTR1DHTR1BHTR6HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534796-B2 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-19 | — | — | US | disclosed |
| US-20060189617-A1 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189617-A1 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor | GNRHR, PRLHR, FSHR | AURKA 1768/4885HTR1A 310/4885HTR1D 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.