Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44570 | 0.88 | CNR1 (0.40) | POLBKMT2APIK3CDPIK3CGNR3C2 | |
| SCHEMBL44400 | 0.88 | ALDH1A1 (0.45) | POLBKMT2AALDH1A1PIK3CDPIK3CG | |
| SCHEMBL44668 | 0.81 | CYP19A1 (0.56) | POLBKMT2AALDH1A1MAPTPIK3CD | |
| SCHEMBL44344 | 0.80 | TP53 (0.45) | KMT2ASMN1; SMN2ALDH1A1PIK3CDPIK3CG | |
| SCHEMBL12926166 | 0.78 | PIK3CD (0.41) | POLBKMT2AALDH1A1MAPTPIK3CD | |
| SCHEMBL38873 | 0.78 | CYP19A1 (0.47) | ALDH1A1PIK3CDPIK3CGNR3C2BRD4 | |
| SCHEMBL44557 | 0.77 | KMT2A (0.40) | TSHRPOLBKMT2AHTTSMN1; SMN2 | |
| SCHEMBL44258 | 0.77 | CYP19A1 (0.60) | POLBKMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13844941 | 0.76 | WDR5 (0.42) | TSHRKMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL22489446 | 0.76 | PRMT6 (0.55) | TSHRPOLBHTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |