Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128093 | 0.77 | BCHE (0.38) | MGLLRAB9AALDH1A1KCNN4 | |
| SCHEMBL8626349 | 0.77 | ALDH1A1 (0.42) | MGLLALDH1A1MAPTKCNN4GSK3B | |
| SCHEMBL11349994 | 0.70 | KMT2A (0.39) | MGLLNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL8513179 | 0.65 | MGLL (0.37) | MGLLNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL3260347 | 0.63 | ALDH1A1 (0.58) | NPC1ALDH1A1MAPT | |
| SCHEMBL15434896 | 0.62 | MGLL (0.62) | MGLLNPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL5546019 | 0.61 | KCNN4 (0.49) | MGLLNPC1RAB9AALDH1A1KCNN4 | |
| SCHEMBL28456095 | 0.60 | KCNN4 (0.44) | MGLLNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL6321042 | 0.60 | KCNN4 (0.44) | MGLLNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL8879382 | 0.60 | MAPT (0.46) | NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576094-B2 | Spiro derivatives as lipoxygenase inhibitors | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | disclosed |
| US-20080207588-A1 | Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines | CHU DANIEL T W | 2008-08-28 | — | — | US | disclosed |
| US-20060193797-A1 | Chroman derivatives as lipoxygenase inhibitors | GALILEO PHARMACEUTICALS, INC | 2006-08-31 | — | — | US | disclosed |
| US-20060128790-A1 | Spiro derivatives as lipoxygenase inhibitors | GALILEO PHARMACEUTICALS, INC. | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207588-A1 | Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines | CBR3, CBR1, DHRS9 | MGLL 1991/4885NPC1 2133/4885RAB9A 611/4885 |
| US-20060193797-A1 | Chroman derivatives as lipoxygenase inhibitors | NR0B1, ALOX5, ALOX15B | MGLL 1290/4885NPC1 3414/4885RAB9A 3178/4885 |
| US-20060128790-A1 | Spiro derivatives as lipoxygenase inhibitors | ALOX15B, ALOX5, ALOX15 | MGLL 284/4885NPC1 1135/4885RAB9A 3169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.