Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.45 |
| ▸ | FLT4 | P35916 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196234 | 0.82 | KDM4E (0.68) | KDM4EHPGDFLT1FLT4KDR | |
| SCHEMBL4457676 | 0.77 | EGFR (0.59) | KDM4EHPGDFLT1FLT4KDR | |
| SCHEMBL4465528 | 0.75 | ALDH1A1 (0.49) | KDM4EHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL23918989 | 0.75 | CA9 (0.47) | KDM4EHPGDFLT1FLT4KDR | |
| SCHEMBL6793445 | 0.75 | MMP2 (0.42) | ALDH1A1SMN1; SMN2KMT2AMEN1CA1 | |
| SCHEMBL4477897 | 0.73 | FLT1 (0.67) | KDM4EFLT1FLT4KDRALDH1A1 | |
| SCHEMBL4476657 | 0.73 | HPGD (0.55) | KDM4EHPGDFLT1FLT4KDR | |
| SCHEMBL10636104 | 0.73 | ALDH1A1 (0.49) | KDM4EHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL2294952 | 0.73 | ALDH1A1 (0.48) | KDM4EHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL4202292 | 0.72 | MYC (0.55) | KDM4EHPGDALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067607-A2 | COMBINATIONS OF PDE4 INHIBITORS AND ANTIPSYCHOTICS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-05-28 | — | — | WO | disclosed |