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SCHEMBL4483494

SCHEMBL4483494

CC(C)(C)OC(=O)N1CCC(=O)C(c2ccc(F)cc2)C1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 5/20 0.47
▸ GRM5 P41594 1/20 0.43
▸ GRM1 Q13255 1/20 0.43
▸ DDB1 Q16531 1/20 0.43
▸ CRBN Q96SW2 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ NR1H2 P55055 1/20 0.43
▸ HDAC1 Q13547 2/20 0.42
▸ HDAC2 Q92769 2/20 0.42
▸ ESR2 Q92731 1/20 0.41
▸ PDE4B Q07343 1/20 0.40
▸ MMP13 P45452 1/20 0.40
▸ POLB P06746 1/20 0.39
▸ GPR119 Q8TDV5 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1617581 0.87 RORC (0.48) RORCDDB1CRBNNR1H2GPR119
SCHEMBL5160786 0.87 DDB1 (0.46) RORCDDB1CRBNNR1H2ESR2
SCHEMBL31649176 0.86 USP30 (0.43) RORCDDB1CRBNMEN1KMT2A
SCHEMBL26129251 0.85 HTT (0.44) DDB1CRBNMEN1KMT2ANR1H2
SCHEMBL30988646 0.85 HTT (0.44) DDB1CRBNMEN1KMT2ANR1H2
SCHEMBL27211314 0.85 GRM1 (0.44) GRM5GRM1DDB1CRBNNR1H2
SCHEMBL31549705 0.84 GPR119 (0.50) DDB1CRBNMEN1KMT2ANR1H2
SCHEMBL5156097 0.82 NR1H2 (0.41) GRM5GRM1DDB1CRBNMEN1
SCHEMBL31478622 0.82 DDB1 (0.41) RORCDDB1CRBNNR1H2ESR2
SCHEMBL4006223 0.82 DDB1 (0.46) RORCDDB1CRBNMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3530655-B1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2022-02-09 — — EP disclosed
CN-109843871-B Heterocyclic compounds 武田药品工业株式会社 2021-09-17 — — CN disclosed
EP-3287441-B1 ACYLATED 4-AMINOPIPERIDINES AS INHIBITORS OF SERINE PALMITOYLTRANSFERASE TAKEDA PHARMACEUTICALS CO (JP) 2021-06-09 — — EP disclosed
CN-107848971-B Heterocyclic compounds 武田药品工业株式会社 2021-03-26 — — CN disclosed
US-10676461-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-06-09 — — US disclosed
US-20190263784-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-08-29 — — US disclosed
EP-3530655-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2019-08-28 — — EP disclosed
US-10189785-B2 Heterocyclic compound TAKEDA PHARMACEUTICALS COMPANY LIMITED (JP) 2019-01-29 — — US disclosed
US-20180170874-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-06-21 — — US disclosed
EP-3287441-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2018-02-28 — — EP disclosed
US-20080076783-A1 Cycloalkyl Keto Piperidine Tachykinin Receptor Antagonists MERCK & CO., INC. (US) 2008-03-27 — — US disclosed
CN-101061096-A Cycloalkyl keto piperidine tachykinin receptor antagonists MERCK & CO INC (US) 2007-10-24 — — CN disclosed
US-20070149570-A1 Piperidine derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-06-28 — — US disclosed
WO-2007015588-A1 PIPERIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-08 — — WO disclosed
EP-1748984-A1 PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS Pfizer Products Inc. (US) 2007-02-07 — — EP disclosed
US-20060167052-A1 Piperidine derivative, process for producing the same, and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-07-27 — — US disclosed
WO-2005110987-A1 PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS PFIZER PRODUCTS INC. (US) 2005-11-24 — — WO disclosed
US-20050256164-A1 NK1 and NK3 antagonists PFIZER INC 2005-11-17 — — US disclosed
CN-1671662-A Piperidine derivatives, process for their preparation and their use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2005-09-21 — — CN disclosed
EP-1553084-A1 PIPERIDINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE Takeda Pharmaceutical Company Limited (JP) 2005-07-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10189785-B2 Heterocyclic compound SPTLC1, SPTLC2, NPC1 RORC 2485/4885GRM5 3649/4885GRM1 3547/4885
US-20070149570-A1 Piperidine derivative and use thereof TACR1, OPRL1, TRPV1 RORC 3058/4885GRM5 300/4885GRM1 552/4885
US-20060167052-A1 Piperidine derivative, process for producing the same, and use OPRL1, OXTR, OPRM1 RORC 2424/4885GRM5 463/4885GRM1 407/4885
US-20050256164-A1 NK1 and NK3 antagonists TAC3, TACR1, TACR2 RORC 1418/4885GRM5 488/4885GRM1 944/4885
US-10676461-B2 Heterocyclic compound SPTLC1, SPTLC3, SPTLC2 RORC 3167/4885GRM5 2886/4885GRM1 2762/4885
US-20180170874-A1 HETEROCYCLIC COMPOUND SPTLC1, SPTLC2, NPC1 RORC 2485/4885GRM5 3649/4885GRM1 3547/4885
US-20190263784-A1 HETEROCYCLIC COMPOUND SPTLC1, SPTLC3, SPTLC2 RORC 3167/4885GRM5 2886/4885GRM1 2762/4885
US-20080076783-A1 Cycloalkyl Keto Piperidine Tachykinin Receptor Antagonists TACR1, TACR2, NPSR1 RORC 3745/4885GRM5 584/4885GRM1 515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.