Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504195 | 0.77 | CCR1 (0.38) | MEN1KMT2AKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL4491009 | 0.77 | ALDH1A1 (0.43) | POLBKDM4EDHODHSMN1; SMN2NPC1 | |
| SCHEMBL4498679 | 0.76 | CCNC (0.36) | POLBKDM4ESMN1; SMN2HTTRAB9A | |
| SCHEMBL4496740 | 0.75 | GRM5 (0.39) | POLBMEN1PABPC1KMT2AADORA3 | |
| SCHEMBL4492339 | 0.73 | MAPT (0.34) | POLBMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4487479 | 0.73 | ECE1 (0.33) | ADORA3SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL4488653 | 0.72 | ERCC1 (0.38) | POLBMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL4495534 | 0.71 | GRM5 (0.39) | POLBNPC1RAB9AHCRTR1 | |
| SCHEMBL4490745 | 0.71 | GRIA2 (0.40) | KMT2AKDM4EDHODHMAPK1 | |
| SCHEMBL4492957 | 0.70 | GRIA2 (0.42) | MEN1KMT2AKDM4ETDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |