Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | GBA1 | P04062 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497714 | 0.85 | TRPV1 (0.40) | — | |
| SCHEMBL4504195 | 0.78 | CCR1 (0.38) | GRM5CCR1CCR8RAB9AKDM4E | |
| SCHEMBL4491009 | 0.78 | ALDH1A1 (0.43) | GRM5RAB9AKDM4ENPC1MAPT | |
| SCHEMBL4491753 | 0.75 | POLB (0.35) | RAB9AADORA3KDM4ENPC1MAPT | |
| SCHEMBL4498679 | 0.74 | CCNC (0.36) | RAB9AKDM4EMAPTPOLB | |
| SCHEMBL4488653 | 0.72 | ERCC1 (0.38) | RAB9AKDM4ENPC1MAPTMEN1 | |
| SCHEMBL4490745 | 0.72 | GRIA2 (0.40) | KDM4EKMT2A | |
| SCHEMBL4492339 | 0.72 | MAPT (0.34) | RAB9AKDM4ENPC1TP53MAPT | |
| SCHEMBL4492957 | 0.71 | GRIA2 (0.42) | RAB9AKDM4ENPC1TP53MAPT | |
| SCHEMBL4489152 | 0.70 | TDP1 (0.44) | GRM5RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |