Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.31 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446626 | 0.79 | POLB (0.32) | CASP6POLBKDM4EMEN1USP2 | |
| SCHEMBL2095737 | 0.77 | KDM4E (0.37) | CASP6POLBKDM4EMEN1USP2 | |
| SCHEMBL2094790 | 0.74 | ALDH1A1 (0.34) | CASP6POLBKDM4EMEN1USP2 | |
| SCHEMBL10566263 | 0.74 | GABRA1 (0.46) | POLBKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL5546711 | 0.72 | SLC9A1 (0.40) | CASP6POLBKDM4EMEN1USP2 | |
| SCHEMBL5500798 | 0.70 | ALDH1A1 (0.38) | POLBKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL16992901 | 0.70 | — | — | |
| SCHEMBL2096513 | 0.69 | ALDH1A1 (0.37) | CASP6POLBKDM4EMEN1USP2 | |
| SCHEMBL452969 | 0.67 | USP2 (0.32) | USP2ALDH1A1HPGDTDP1 | |
| SCHEMBL8181122 | 0.67 | AKR1B1 (0.41) | POLBALDH1A1MAPTALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206173-B2 | Heterocyclic compounds for the treatment of stress-related conditions | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-12-08 | — | — | US | disclosed |
| EP-2435046-B1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | OTSUKA PHARMA CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| US-20120065189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-03-15 | — | — | US | disclosed |
| WO-2010137738-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-12-02 | — | — | WO | disclosed |
| US-7250559-B2 | Nucleic acids encoding glucosinolate biosynthesis enzymes and methods of their use | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-07-31 | — | — | US | disclosed |
| US-20050055744-A1 | Nucleic acids encoding glucosinolate biosynthesis enzymes and methods of their use | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-03-10 | — | — | US | disclosed |
| WO-2003004619-A2 | NUCLEIC ACIDS ENCODING GLUCOSINOLATE BIOSYNTHESIS ENZYMES AND METHODS OF THEIR USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF STRESS-RELATED CONDITIONS | NR3C1, NR3C2, CRH | CASP6 3216/4885POLB 4094/4885KDM4E 3857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.