Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535829 | 0.89 | CYP1A2 (0.45) | SIGMAR1ALDH1A1KDM4ENR3C2MAPT | |
| SCHEMBL5653544 | 0.86 | KCNH2 (0.45) | SIGMAR1ALDH1A1MAPTLMNATSHR | |
| SCHEMBL4535886 | 0.83 | CHRNB2 (0.56) | ALDH1A1ALOX5NPC1RAB9AMAOB | |
| SCHEMBL30408958 | 0.83 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1NR3C2MAPTALOX5 | |
| SCHEMBL4525149 | 0.82 | GRM2 (0.40) | SIGMAR1MAOBMAOA | |
| SCHEMBL18041308 | 0.82 | SIGMAR1 (0.46) | SIGMAR1ALDH1A1KDM4ENR3C2MAPT | |
| SCHEMBL5388903 | 0.78 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL4525941 | 0.78 | MEN1 (0.53) | ALDH1A1KDM4EMAPTSMN1; SMN2POLB | |
| SCHEMBL1798916 | 0.78 | L3MBTL1 (0.42) | — | |
| SCHEMBL8217404 | 0.78 | PPARG (0.44) | SIGMAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | PLE PATRICK | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | AQP3, AQP1, F12 | SIGMAR1 158/4885ALDH1A1 2449/4885KDM4E 2349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.