Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MITF | O75030 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4517075 | 0.85 | LMNA (0.46) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL15910484 | 0.85 | LMNA (0.46) | LMNAALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL20300878 | 0.84 | DYRK1A (0.47) | LMNAALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL4518809 | 0.84 | KDM4E (0.51) | LMNAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL4530991 | 0.84 | LMNA (0.46) | LMNAALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL4512861 | 0.84 | HPGDS (0.40) | LMNAHPGDSKDM4ETP53SMN1; SMN2 | |
| SCHEMBL18425278 | 0.81 | KDM4E (0.44) | LMNAALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL29675206 | 0.81 | KDM4E (0.44) | LMNAALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL4523223 | 0.80 | HPGDS (0.43) | ALDH1A1HPGDSKDM4EMAPTKMT2A | |
| SCHEMBL4522982 | 0.80 | LMNA (0.50) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499515-B2 | Method for producing 3,4-dihydroisoquinoline derivatives and production intermediates of same | MITSUI CHEMICALS AGRO, INC. (JP) | 2016-11-22 | — | — | US | disclosed |
| US-9499515-B2 | Method for producing 3,4-dihydroisoquinoline derivatives and production intermediates of same | MITSUI CHEMICALS AGRO, INC. (JP) | 2016-11-22 | — | — | US | disclosed |
| US-9499515-B2 | Method for producing 3,4-dihydroisoquinoline derivatives and production intermediates of same | MITSUI CHEMICALS AGRO, INC. (JP) | 2016-11-22 | — | — | US | disclosed |
| EP-2762474-B1 | PRODUCTION METHODS FOR 3,4-DIHYDROISOQUINOLINE DERIVATIVES, AND PRODUCTION INTERMEDIATES FOR SAME | MITSUI CHEMICALS AGRO INC (JP) | 2016-02-24 | — | — | EP | disclosed |
| EP-2762474-B1 | PRODUCTION METHODS FOR 3,4-DIHYDROISOQUINOLINE DERIVATIVES, AND PRODUCTION INTERMEDIATES FOR SAME | MITSUI CHEMICALS AGRO INC (JP) | 2016-02-24 | — | — | EP | disclosed |
| US-20160039786-A1 | METHOD FOR PRODUCING 3,4-DIHYDROISOQUINOLINE DERIVATIVES AND PRODUCTION INTERMEDIATES OF SAME | MITSUI CHEMICALS AGRO, INC. (JP) | 2016-02-11 | — | — | US | disclosed |
| US-20160039786-A1 | METHOD FOR PRODUCING 3,4-DIHYDROISOQUINOLINE DERIVATIVES AND PRODUCTION INTERMEDIATES OF SAME | MITSUI CHEMICALS AGRO, INC. (JP) | 2016-02-11 | — | — | US | disclosed |
| US-20160039786-A1 | METHOD FOR PRODUCING 3,4-DIHYDROISOQUINOLINE DERIVATIVES AND PRODUCTION INTERMEDIATES OF SAME | MITSUI CHEMICALS AGRO, INC. (JP) | 2016-02-11 | — | — | US | disclosed |
| US-9193706-B2 | Method for producing 3,4-dihydroisoquinoline derivatives and production intermediates of same | MITSUI CHEMICALS AGRO, INC. (JP) | 2015-11-24 | — | — | US | disclosed |
| US-9193706-B2 | Method for producing 3,4-dihydroisoquinoline derivatives and production intermediates of same | MITSUI CHEMICALS AGRO, INC. (JP) | 2015-11-24 | — | — | US | disclosed |
| US-20140228576-A1 | METHOD FOR PRODUCING 3,4-DIHYDROISOQUINOLINE DERIVATIVES AND PRODUCTION INTERMEDIATES OF SAME | MITSUI CHEMICALS AGRO, INC. (JP) | 2014-08-14 | — | — | US | disclosed |
| US-20140228576-A1 | METHOD FOR PRODUCING 3,4-DIHYDROISOQUINOLINE DERIVATIVES AND PRODUCTION INTERMEDIATES OF SAME | MITSUI CHEMICALS AGRO, INC. (JP) | 2014-08-14 | — | — | US | disclosed |
| EP-2762474-A1 | PRODUCTION METHODS FOR 3,4-DIHYDROISOQUINOLINE DERIVATIVES, AND PRODUCTION INTERMEDIATES FOR SAME | Mitsui Chemicals Agro, Inc. (JP) | 2014-08-06 | — | — | EP | disclosed |
| CN-103814022-A | Process for producing 3, 4-dihydroisoquinoline derivative and intermediate for producing the same | MITSUI CHEMICALS AGRO INC | 2014-05-21 | — | — | CN | disclosed |
| EP-1736471-B1 | 3-(DIHYDRO(TETRAHYDRO)ISOQUINOLIN-1-YL)QUINOLINES | MITSUI CHEMICALS AGRO INC (JP) | 2014-01-08 | — | — | EP | disclosed |
| US-7632783-B2 | fungicides, pesticides for protecting rice crop, tomatoes, cucumbers and green beans; 3-(5-fluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline | MITSUI CHEMICALS AGRO, INC. (JP) | 2009-12-15 | — | — | US | disclosed |
| CN-100556904-C | 3- (dihydro (tetrahydro) isoquinolin-1-yl) quinoline compounds | SANKYO AGRO CO LTD (JP) | 2009-11-04 | — | — | CN | disclosed |
| US-20080275242-A1 | 3-(Dihydro(Tetrahydro)Isoquinolin-1-Yl)Quinoline Compound | MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) | 2008-11-06 | — | — | US | disclosed |
| CN-1910172-A | 3- (dihydro (tetrahydro) isoquinolin-1-yl) quinoline compounds | SANKYO AGRO CO LTD (JP) | 2007-02-07 | — | — | CN | disclosed |
| EP-1736471-A1 | 3-(DIHYDRO(TETRAHYDRO)ISOQUINOLIN-1-YL)QUINOLINES | Sankyo Agro Company, Limited (JP) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039786-A1 | METHOD FOR PRODUCING 3,4-DIHYDROISOQUINOLINE DERIVATIVES AND PRODUCTION INTERMEDIATES OF SAME | SDHA, NDUFS3, GOT2 | LMNA 3015/4885ALDH1A1 186/4885HPGDS 859/4885 |
| US-20080275242-A1 | 3-(Dihydro(Tetrahydro)Isoquinolin-1-Yl)Quinoline Compound | QTRT1, RABL3, RECQL | LMNA 2721/4885ALDH1A1 1185/4885HPGDS 4660/4885 |
| US-20140228576-A1 | METHOD FOR PRODUCING 3,4-DIHYDROISOQUINOLINE DERIVATIVES AND PRODUCTION INTERMEDIATES OF SAME | SDHA, NDUFS3, GOT2 | LMNA 3015/4885ALDH1A1 186/4885HPGDS 859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.