SCHEMBL4534347

SCHEMBL4534347

O=C(O)N1CCC(C2OCc3cc(-c4ccc(-c5nnn[nH]5)cc4)ccc3O2)CC1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR142 Q7Z601 2/20 0.32
GPR119 Q8TDV5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4533479 0.87 PTPN2 (0.43) GPR119
SCHEMBL4529829 0.83 GPR142 (0.43) GPR142
SCHEMBL4535866 0.80 GPR119 (0.36) GPR119
SCHEMBL4347925 0.79 USP30 (0.40) GPR119
SCHEMBL4540933 0.78 CYP11B1 (0.44)
SCHEMBL4538463 0.78 NPY2R (0.39) GPR119
SCHEMBL4534161 0.78 SCD5 (0.41) GPR119
SCHEMBL4360517 0.77 NAMPT (0.41) GPR119
SCHEMBL4357683 0.77 POLB (0.48) GPR119
SCHEMBL4533028 0.77 HPGD (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009150144-A1 NEW GPR119MODULATORS INOVACIA AB (SE) 2009-12-17 WO disclosed