Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537565 | 0.85 | RAB9A (0.51) | HPGDFKBP1AMAPK1 | |
| SCHEMBL8064982 | 0.85 | HSD11B1 (0.45) | HSD11B1FKBP1ALMNAMAPK1SMN1; SMN2 | |
| SCHEMBL4541859 | 0.82 | RAB9A (0.54) | HPGDGAA | |
| SCHEMBL4534536 | 0.81 | FKBP1A (0.52) | HPGDFKBP1ALMNAMAPK1SMN1; SMN2 | |
| SCHEMBL4533522 | 0.80 | KMT2A (0.44) | HPGD | |
| SCHEMBL8058698 | 0.80 | KMT2A (0.44) | HPGD | |
| SCHEMBL4531364 | 0.80 | HSD11B1 (0.44) | HSD11B1HPGDLMNAGAA | |
| SCHEMBL4537337 | 0.79 | ATM (0.46) | HSD11B1HPGDLMNAGAA | |
| SCHEMBL4536848 | 0.79 | HTR1A (0.48) | — | |
| SCHEMBL4535257 | 0.78 | RAB9A (0.53) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |