Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 7/20 | 0.43 |
| ▸ | AKT2 | P31751 | 3/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | PRKCB | P05771 | 2/20 | 0.43 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | PRKACB | P22694 | 2/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3332940 | 0.82 | AKT1 (0.61) | AKT1AKT2AKT3ROCK2ROCK1 | |
| SCHEMBL3333948 | 0.80 | AKT1 (0.47) | AKT1AKT2AKT3ROCK2ROCK1 | |
| SCHEMBL13300065 | 0.79 | AKT1 (0.48) | AKT1AKT2AKT3ROCK2ROCK1 | |
| SCHEMBL4540065 | 0.79 | AKT1 (0.45) | AKT1AKT2AKT3ROCK2ROCK1 | |
| SCHEMBL4553029 | 0.76 | TRPM8 (0.41) | ROCK2ROCK1HTR2A | |
| SCHEMBL4554202 | 0.76 | CTSV (0.42) | ROCK2ROCK1 | |
| SCHEMBL3330540 | 0.74 | ROCK2 (0.59) | AKT1AKT2AKT3ROCK2ROCK1 | |
| SCHEMBL4541583 | 0.73 | ITGB1 (0.38) | AKT1AKT2AKT3ROCK2ROCK1 | |
| SCHEMBL4541109 | 0.73 | AKT1 (0.53) | AKT1AKT2AKT3ROCK2ROCK1 | |
| SCHEMBL3259169 | 0.73 | AKT1 (0.46) | AKT1AKT2AKT3ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |