Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537575 | 0.95 | ALDH1A1 (0.49) | EPHX1EPHX2GFERLMNAALDH1A1 | |
| SCHEMBL4542983 | 0.94 | EPHX1 (0.57) | EPHX1EPHX2GFERLMNAALDH1A1 | |
| SCHEMBL4536776 | 0.89 | LMNA (0.62) | EPHX1EPHX2LMNAALDH1A1TSHR | |
| SCHEMBL4539274 | 0.89 | CYP3A4 (0.51) | EPHX1EPHX2LMNAALDH1A1TSHR | |
| SCHEMBL4540431 | 0.89 | NPC1 (0.55) | EPHX1EPHX2LMNAALDH1A1TSHR | |
| SCHEMBL4540032 | 0.89 | PKM (0.51) | EPHX1EPHX2LMNAALDH1A1TSHR | |
| SCHEMBL4537257 | 0.88 | LMNA (0.51) | EPHX1EPHX2LMNAALDH1A1TSHR | |
| SCHEMBL4543052 | 0.88 | NPC1 (0.48) | EPHX1EPHX2LMNAALDH1A1TSHR | |
| SCHEMBL4542516 | 0.88 | LMNA (0.49) | EPHX1EPHX2LMNAALDH1A1TSHR | |
| SCHEMBL4537966 | 0.85 | LMNA (0.57) | EPHX1EPHX2GFERLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |