Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551382 | 0.79 | KDM4E (0.42) | SLC6A2SLC6A4SLC6A3RENTACR1 | |
| SCHEMBL4544203 | 0.78 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3RENMEN1 | |
| SCHEMBL3972925 | 0.78 | MAPK1 (0.44) | MC4RSLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL3931492 | 0.77 | REN (0.41) | MC4RSLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL3973911 | 0.77 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL3973856 | 0.76 | L3MBTL1 (0.47) | RENMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3973369 | 0.75 | REN (0.43) | SLC6A2SLC6A4SLC6A3RENKCNH2 | |
| SCHEMBL3973450 | 0.74 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3RENKCNH2 | |
| SCHEMBL3974286 | 0.74 | REN (0.43) | RENMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3974580 | 0.74 | REN (0.41) | SLC6A2SLC6A4RENMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |