Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | BLM | P54132 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | TYMS | P04818 | 1/20 | 0.50 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.43 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 2/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | OTC | P00480 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL2852681 | 0.97 | ALDH1A1 (0.75) | ALDH1A1LMNABLMCYP3A4NFKB1 | |
| Ethylenediamine SCHEMBL241966 | 0.97 | ALDH1A1 (0.75) | ALDH1A1LMNABLMCYP3A4NFKB1 | |
| Ethylenediamine SCHEMBL15053407 | 0.88 | LMNA (0.74) | ALDH1A1LMNABLMCYP3A4NFKB1 | |
| Ethylenediamine SCHEMBL69119 | 0.84 | LMNA (0.78) | ALDH1A1LMNABLMCYP3A4NFKB1 | |
| Ethylenediamine SCHEMBL10933099 | 0.84 | LMNA (0.78) | ALDH1A1LMNABLMCYP3A4NFKB1 | |
| Monoethanolamine SCHEMBL6443000 | 0.84 | ALDH1A1 (0.67) | ALDH1A1LMNABLMCYP3A4NFKB1 | |
| Monoethanolamine SCHEMBL8591801 | 0.84 | ALDH1A1 (0.67) | ALDH1A1LMNABLMCYP3A4NFKB1 | |
| SCHEMBL80285 | 0.83 | — | — | |
| SCHEMBL8352725 | 0.82 | TYMS (0.69) | ALDH1A1LMNABLMCYP3A4NFKB1 | |
| SCHEMBL81370 | 0.82 | TYMS (0.69) | ALDH1A1LMNABLMCYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120064535-A1 | METHOD OF PREPARING SAMPLES CONTAINING NUCLEIC ACIDS | OLYMPUS CORPORATION (JP) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064535-A1 | METHOD OF PREPARING SAMPLES CONTAINING NUCLEIC ACIDS | ADAR, POLRMT, NOP2 | ALDH1A1 2312/4885LMNA 356/4885BLM 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.