Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.34 |
| ▸ | CDK2 | P24941 | 6/20 | 0.34 |
| ▸ | CDK4 | P11802 | 4/20 | 0.34 |
| ▸ | CCND1 | P24385 | 4/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10220808 | 0.81 | CCNE2 (0.36) | ALDH1A1MAPTPLA2G1BATG4BLMNA | |
| SCHEMBL21237253 | 0.81 | NUDT1 (0.41) | CA2ALDH1A1ADORA2AADORA1 | |
| SCHEMBL10220806 | 0.81 | MAPT (0.44) | ALDH1A1MAPTPLA2G1BATG4BLMNA | |
| SCHEMBL24174451 | 0.78 | TLR7 (0.34) | CA2ALDH1A1MAPTPLA2G1BATG4B | |
| SCHEMBL25054655 | 0.74 | TNF (0.43) | ALDH1A1MAPTLMNAADORA2AADORA1 | |
| SCHEMBL24768886 | 0.74 | LMNA (0.56) | ALDH1A1MAPTPLA2G1BATG4BLMNA | |
| SCHEMBL322264 | 0.73 | CYP1A2 (0.42) | ALDH1A1MAPTPLA2G1BATG4BLMNA | |
| SCHEMBL22210786 | 0.73 | ADORA2A (0.30) | ADORA2AADORA1 | |
| SCHEMBL22940105 | 0.73 | GPR3 (0.47) | CA2ALDH1A1MAPTATMELANE | |
| SCHEMBL20127241 | 0.73 | CA2 (0.38) | CA2ALDH1A1GABRA1GABRB2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176774-A1 | Compounds and methods of use | HGF, HGFAC, MET | CA2 2785/4885ALDH1A1 81/4885MAPT 2653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.