SCHEMBL4550397

SCHEMBL4550397

NCc1cc(OC(F)(F)F)ccc1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.44
GPR3 P46089 3/20 0.42
MAOB P27338 1/20 0.41
AOC3 Q16853 1/20 0.41
ADRB2 P07550 1/20 0.41
FFAR4 Q5NUL3 4/20 0.40
KIF11 P52732 2/20 0.40
ALKBH1 Q13686 1/20 0.40
FFAR1 O14842 2/20 0.40
TRPV1 Q8NER1 1/20 0.38
NPC1 O15118 1/20 0.38
GMNN O75496 1/20 0.38
USP2 O75604 1/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
GAA P10253 1/20 0.38
CYP2C9 P11712 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29786515 1.00 MPO (0.44) MPOGPR3MAOBAOC3ADRB2
Hydrochloric Acid SCHEMBL29786592 0.98 MPO (0.43) MPOGPR3MAOBAOC3ADRB2
SCHEMBL20472423 0.88 MPO (0.42) MPOGPR3MAOBAOC3ADRB2
SCHEMBL20472377 0.87 TAAR1 (0.47) MPOGPR3MAOBAOC3ADRB2
SCHEMBL31508223 0.85 GPR3 (0.42) GPR3MAOBAOC3FFAR4KIF11
SCHEMBL16037391 0.85 GPR3 (0.42) GPR3MAOBAOC3FFAR4KIF11
Hydrochloric Acid SCHEMBL31594003 0.84 GPR3 (0.41) GPR3MAOBAOC3FFAR4KIF11
SCHEMBL15599254 0.81 PDE2A (0.44) MPOGPR3ADRB2FFAR4ALKBH1
SCHEMBL10978751 0.81 GPR3 (0.42) MPOGPR3ADRB2FFAR4KIF11
SCHEMBL11030156 0.81 FFAR4 (0.49) MPOGPR3MAOBAOC3ADRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4105216-B1 DIHYDRONAPHTHYRIDINONE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF GENFLEET THERAPEUTICS SHANGHAI INC (CN) 2026-05-20 EP disclosed
WO-2025080100-A1 NOVEL DI-AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER OR AUTOIMMUNE DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT 한국화학연구원 2025-04-17 WO disclosed
US-12275721-B2 Indazole carboxamides as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-15 US disclosed
US-20250074909-A1 AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2025-03-06 US disclosed
WO-2025016457-A1 NEW SUBSTITUTED HETEROCYCLIC COMPOUND AS GSPTS/MYC SIGNAL FLUX REGULATOR 杭州德睿智药科技有限公司 2025-01-23 WO disclosed
US-12157733-B2 Aminotriazolopyridines as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2024-12-03 US disclosed
US-20240360121-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-10-31 US disclosed
US-20240352040-A1 CRYSTAL FORM OF RIPK1 INHIBITOR, ACID SALT THEREOF, AND CRYSTAL FORM OF ACID SALT THEREOF GENFLEET THERAPEUTICS (SHANGHAI) INC. (CN) 2024-10-24 US disclosed
EP-4382528-A1 CRYSTAL FORM OF RIPK1 INHIBITOR, ACID SALT THEREOF, AND CRYSTAL FORM OF ACID SALT THEREOF Genfleet Therapeutics (Shanghai) Inc. (CN) 2024-06-12 EP disclosed
US-11958849-B2 GLS1 inhibitors for treating disease BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-04-16 US disclosed
WO-2016004417-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004404-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004404-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004413-A2 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
WO-2016004417-A1 GLS1 INHIBITORS FOR TREATING DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2016-01-07 WO disclosed
US-20150157611-A1 COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE I ENZYME KAINOS MEDICINE, INC. (KR) 2015-06-11 US disclosed
US-20140336377-A1 ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC. (JP) 2014-11-13 US disclosed
US-20140336377-A1 ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC. (JP) 2014-11-13 US disclosed
WO-2013119040-A1 COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME KAINOS MEDICINE, INC. (KR) 2013-08-15 WO disclosed
WO-2012053186-A1 ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS RAQUALIA PHARMA INC. (JP) 2012-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150157611-A1 COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE I ENZYME DGAT1, DGAT2, SOAT1 MPO 630/4885GPR3 2206/4885MAOB 844/4885
US-20240360121-A1 GLS1 INHIBITORS FOR TREATING DISEASE GLS2, GLS, GLG1 MPO 3305/4885GPR3 1002/4885MAOB 2962/4885
US-20140336377-A1 ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS SCN2B, SCN1B, SCN2A MPO 1299/4885GPR3 689/4885MAOB 220/4885
US-20240352040-A1 CRYSTAL FORM OF RIPK1 INHIBITOR, ACID SALT THEREOF, AND CRYSTAL FORM OF ACID SALT THEREOF RIPK1, RIPK4, RIPK2 MPO 3028/4885GPR3 4383/4885MAOB 4527/4885
US-20250074909-A1 AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS RIPK1, RIPK3, RIPK4 MPO 3804/4885GPR3 1039/4885MAOB 3963/4885
US-12275721-B2 Indazole carboxamides as kinase inhibitors RIPK3, RIPK1, RIPK2 MPO 4238/4885GPR3 1010/4885MAOB 4127/4885
US-11958849-B2 GLS1 inhibitors for treating disease GLS2, GLS, GLG1 MPO 3305/4885GPR3 1002/4885MAOB 2962/4885
US-12157733-B2 Aminotriazolopyridines as kinase inhibitors RIPK1, RIPK3, RIPK4 MPO 3804/4885GPR3 1039/4885MAOB 3963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.