Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 4/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551429 | 0.87 | KDM5A (0.48) | KDM5AMAPK8ADORA2AADORA3ADORA1 | |
| SCHEMBL6362477 | 0.75 | PGR (0.68) | MAPK8PGRKMT2AKDM4EALDH1A1 | |
| SCHEMBL30485670 | 0.75 | PGR (0.68) | MAPK8PGRKMT2AKDM4EALDH1A1 | |
| SCHEMBL12060489 | 0.75 | KDM5A (0.46) | KDM5AGABRA5KDM4EALDH1A1GAA | |
| SCHEMBL2220005 | 0.72 | ALDH1A1 (0.55) | KDM5AROCK2KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3842265 | 0.71 | KDM5A (0.49) | KDM5AADORA2AADORA3ROCK2KDM4E | |
| SCHEMBL17434540 | 0.71 | ADORA2A (0.45) | MAPK8ADORA2AMETAP2ADORA2BKMT2A | |
| SCHEMBL13819107 | 0.70 | ADORA3 (0.53) | KDM5AADORA2AADORA3ADORA1ALDH1A1 | |
| SCHEMBL21676745 | 0.69 | DYRK1A (0.43) | KDM5AADORA2AADORA3ADORA1GABRA5 | |
| SCHEMBL19271310 | 0.69 | ROCK2 (0.47) | KDM5AMETAP2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108597-A1 | Azaquinazolinediones Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108597-A1 | Azaquinazolinediones Chymase Inhibitors | CMA1, SERPINB1, CTSC | KDM5A 745/4885MAPK8 3561/4885ADORA2A 4651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.