Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.67 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545778 | 0.90 | PTGS2 (0.62) | PTGS2HCRTR1ALDH1A1MAPTMEN1 | |
| SCHEMBL9250989 | 0.86 | HCRTR1 (0.53) | PTGS2HCRTR1ALDH1A1MAPTMEN1 | |
| SCHEMBL12103324 | 0.85 | PTGS2 (0.57) | PTGS2HCRTR1ALDH1A1MAPTMEN1 | |
| SCHEMBL23145504 | 0.82 | PTGS2 (0.97) | PTGS2ALDH1A1MAPTHSD17B10KDM4E | |
| SCHEMBL29754289 | 0.82 | PTGS2 (0.97) | PTGS2ALDH1A1MAPTHSD17B10KDM4E | |
| SCHEMBL9085960 | 0.82 | ALDH1A1 (0.50) | PTGS2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11327533 | 0.81 | NAAA (0.63) | PTGS2HCRTR1ALDH1A1MEN1KMT2A | |
| SCHEMBL9084521 | 0.81 | HCRTR1 (0.59) | PTGS2HCRTR1ALDH1A1MEN1KMT2A | |
| SCHEMBL5605205 | 0.81 | PTGS2 (1.00) | PTGS2ALDH1A1MAPTHSD17B10KDM4E | |
| SCHEMBL18334051 | 0.81 | PTGS2 (0.62) | PTGS2HCRTR1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540544-B1 | BENZOIC ACID SUBSTITUTED DERIVATIVES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO SPA (IT) | 1995-02-15 | — | — | EP | claimed |
| WO-1992001668-A1 | BENZOIC ACID SUBSTITUTED DERIVATIVES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO S.P.A. (IT) | 1992-02-06 | — | — | WO | claimed |
| US-7544711-B2 | Use of nitroderivatives in urinary incontinence | NICOX S.A. (FR) | 2009-06-09 | — | — | US | disclosed |
| US-20050101661-A1 | Use of nitroderivatives in urinary incontinence | NICOX S.A. (FR) | 2005-05-12 | — | — | US | disclosed |
| EP-1473288-A1 | Nitric ester derivatives of COX-2 inhibitors and their use for treating inflammation and cardiovascular diseases | Nicox S.A. (FR) | 2004-11-03 | — | — | EP | disclosed |
| EP-1437132-A1 | Use of nitric ester derivatives in the manufacture of a medicament for the treatment of gastrointestinal tumors | Nicox S.A (FR) | 2004-07-14 | — | — | EP | disclosed |
| US-20040082652-A1 | Nitric ester derivatives and their use in treating gastrointestinal tumors | NICOX S.A. | 2004-04-29 | — | — | US | disclosed |
| EP-0759899-B1 | NITRO COMPOUNDS AND THEIR COMPOSITIONS HAVING ANTI-INFLAMMATORY, ANALGESIC AND ANTI-THROMBOTIC ACITIVITIES | NICOX SA (FR) | 1999-09-15 | — | — | EP | disclosed |
| EP-0931065-A2 | NITRIC ESTER DERIVATIVES AND THEIR USE IN URINARY INCONTINENCE AND OTHER DISEASES | NICOX S.A. (FR) | 1999-07-28 | — | — | EP | disclosed |
| US-5861426-A | NITRO ESTERS OF AROMATIC COMPOUNDS WITH AMIDE OR ESTER GROUPS | NICOX S.A. (FR) | 1999-01-19 | — | — | US | disclosed |
| WO-1998009948-A2 | NITRIC ESTER DERIVATIVES AND THEIR USE IN URINARY INCONTINENCE AND OTHER DISEASES | NICOX S.A. (FR) | 1998-03-12 | — | — | WO | disclosed |
| US-5589490-A | BENZAMIDE DERIVATIVES WITH NITROXY ALKYL GROUPS | ITALFARMACO S.P.A. (IT) | 1996-12-31 | — | — | US | disclosed |
| WO-1995030641-A1 | NITRO COMPOUNDS AND THEIR COMPOSITIONS HAVING ANTI-INFLAMMATORY, ANALGESIC AND ANTI-THROMBOTIC ACITIVITIES | NICOX S.A. (FR) | 1995-11-16 | — | — | WO | disclosed |
| EP-0540544-B1 | BENZOIC ACID SUBSTITUTED DERIVATIVES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO SPA (IT) | 1995-02-15 | — | — | EP | disclosed |
| US-5366992-A | IN MIXTURE WITH AN EXCIPIENT | ITALFARMACO S.P.A. (IT) | 1994-11-22 | — | — | US | disclosed |
| EP-0540544-A1 | BENZOIC ACID SUBSTITUTED DERIVATIVES HAVING CARDIOVASCULAR ACTIVITY. | ITALFARMACO SPA (IT) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001668-A1 | BENZOIC ACID SUBSTITUTED DERIVATIVES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO S.P.A. (IT) | 1992-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082652-A1 | Nitric ester derivatives and their use in treating gastrointestinal tumors | NOS1, PTGER1, NOS3 | PTGS2 62/4885HCRTR1 495/4885ALDH1A1 711/4885 |
| US-20050101661-A1 | Use of nitroderivatives in urinary incontinence | NR0B1, NOX1, AKR1C1 | PTGS2 1068/4885HCRTR1 671/4885ALDH1A1 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.