Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783437 | 0.89 | NAMPT (0.65) | NAMPTNPC1RAB9APKMKCNK3 | |
| SCHEMBL14223876 | 0.86 | NPC1 (0.56) | NAMPTNPC1RAB9ALMNAHIF1A | |
| SCHEMBL14223443 | 0.85 | RAB9A (0.48) | NAMPTNPC1RAB9ALMNAHIF1A | |
| SCHEMBL4856199 | 0.85 | CYP11B1 (0.51) | NAMPTNPC1RAB9ALMNAHIF1A | |
| SCHEMBL4854969 | 0.81 | RAB9A (0.70) | NAMPTNPC1RAB9ALMNAKMT2A | |
| SCHEMBL4854662 | 0.81 | KMT2A (0.52) | NPC1RAB9AROCK2ROCK1KMT2A | |
| SCHEMBL4863530 | 0.81 | KDM4E (0.59) | NPC1RAB9ALMNAKMT2AALDH1A1 | |
| SCHEMBL393417 | 0.80 | ALDH1A1 (0.48) | NPC1RAB9APKMKCNK3KMT2A | |
| SCHEMBL5779983 | 0.79 | JAK2 (0.61) | NAMPTNPC1RAB9AKCNK3LMNA | |
| SCHEMBL5594818 | 0.79 | ALDH1A1 (0.54) | NAMPTNPC1RAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124463-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2024-04-18 | — | — | US | disclosed |
| EP-4321513-A2 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | Incyte Corporation (US) | 2024-02-14 | — | — | EP | disclosed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| US-11591338-B2 | Pyrrolotriazine compounds as TAM inhibitors | INCYTE CORPORATION (US) | 2023-02-28 | — | — | US | disclosed |
| US-20210147430-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2021-05-20 | — | — | US | disclosed |
| US-20210147430-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2021-05-20 | — | — | US | disclosed |
| US-10844069-B2 | Pyrrolotriazine compounds as TAM inhibitors | INCYTE CORPORATION (US) | 2020-11-24 | — | — | US | disclosed |
| US-10844069-B2 | Pyrrolotriazine compounds as TAM inhibitors | INCYTE CORPORATION (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200131185-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION | 2020-04-30 | — | — | US | disclosed |
| US-20160276603-A1 | Organic Electroluminescent Materials and Devices | UNIVERSAL DISPLAY CORPORATION | 2016-09-22 | — | — | US | disclosed |
| US-20160276603-A1 | Organic Electroluminescent Materials and Devices | UNIVERSAL DISPLAY CORPORATION | 2016-09-22 | — | — | US | disclosed |
| US-20160024020-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | FMC CORPORATION | 2016-01-28 | — | — | US | disclosed |
| US-9187432-B2 | Intermediates to prepare herbicidal pyrimidone derivatives | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150105549-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | FMC CORPORATION | 2015-04-16 | — | — | US | disclosed |
| US-8952024-B2 | Herbicidal pyrimidone derivatives | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-02-10 | — | — | US | disclosed |
| EP-2475654-A1 | HERBICIDAL PYRIMIDONE DERIVATIVES | E. I. du Pont de Nemours and Company (US) | 2012-07-18 | — | — | EP | disclosed |
| US-20120149573-A1 | HERBICIDAL BUS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES | FMC CORPORATION | 2012-06-14 | — | — | US | disclosed |
| WO-2012033548-A2 | HERBICIDAL BIS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |
| WO-2011031658-A1 | HERBICIDAL PYRIMIDONE DERIVATIVES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160276603-A1 | Organic Electroluminescent Materials and Devices | EML4, BICRA, TBCB | NAMPT 830/4885NPC1 4802/4885RAB9A 2207/4885 |
| US-20120149573-A1 | HERBICIDAL BUS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES | CBR3, CYP1B1, CBR1 | NAMPT 3914/4885NPC1 3841/4885RAB9A 2193/4885 |
| US-20210147430-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MERTK, MAP3K15, MAP3K5 | NAMPT 423/4885NPC1 3819/4885RAB9A 2040/4885 |
| US-10844069-B2 | Pyrrolotriazine compounds as TAM inhibitors | MERTK, MAP3K15, MAP3K5 | NAMPT 423/4885NPC1 3819/4885RAB9A 2040/4885 |
| US-20200131185-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MERTK, MAP3K15, MAP3K5 | NAMPT 423/4885NPC1 3819/4885RAB9A 2040/4885 |
| US-20150105549-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | CBR3, CBR1, MSRB3 | NAMPT 1064/4885NPC1 4667/4885RAB9A 2164/4885 |
| US-11591338-B2 | Pyrrolotriazine compounds as TAM inhibitors | MERTK, MAP3K15, MAP3K5 | NAMPT 423/4885NPC1 3819/4885RAB9A 2040/4885 |
| US-20160024020-A1 | INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES | CBR3, CBR1, PNPO | NAMPT 1017/4885NPC1 4644/4885RAB9A 2039/4885 |
| US-20240124463-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | MERTK, MAP3K15, MAP3K5 | NAMPT 423/4885NPC1 3819/4885RAB9A 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.