Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.33 |
| ▸ | PLG | P00747 | 3/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.33 |
| ▸ | MMP13 | P45452 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | YAP1 | P46937 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452679 | 0.86 | CTSB (0.32) | ITGB3ITGA2B | |
| SCHEMBL4556761 | 0.84 | PLAU (0.43) | PLAUPLGF2F10ST14 | |
| SCHEMBL4556596 | 0.81 | PLAU (0.41) | PLAUPLGF2F10ST14 | |
| SCHEMBL4557815 | 0.78 | ITGB3 (0.42) | PLAUPLGF2F10ST14 | |
| SCHEMBL4459041 | 0.68 | ITGB3 (0.36) | PLAUPLGF2F10ST14 | |
| SCHEMBL6129266 | 0.67 | PLAU (0.61) | PLAUPLGF2F10ST14 | |
| SCHEMBL13795553 | 0.65 | PLAU (0.64) | PLAUPLGF2F10ST14 | |
| SCHEMBL2243219 | 0.62 | ADAMTS4 (0.37) | PLAUPLGF2F10ITGB3 | |
| SCHEMBL6551292 | 0.61 | MGLL (0.30) | — | |
| Hydrochloric Acid SCHEMBL6550006 | 0.61 | PLAU (0.35) | PLAUPLGF2F10ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511721-B1 | GUANIDINO PHENYLALANIN COMPOUNDS USED AS UROKINASE INHIBITORS | WILEX AG (DE) | 2009-07-01 | — | — | EP | disclosed |
| EP-1511721-A2 | GUANIDINO PHENYLALANIN COMPOUNDS USED AS UROKINASE INHIBITORS | Wilex AG (DE) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003103644-A2 | GUANIDINO PHENYLALANIN COMPOUNDS USED AS UROKINASE INHIBITORS | WILEX AG (DE) | 2003-12-18 | — | — | WO | disclosed |