SCHEMBL455982

SCHEMBL455982

COc1cc(F)ccc1N

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.61
CYP3A4 P08684 3/20 0.61
TDP1 Q9NUW8 2/20 0.61
TSHR P16473 1/20 0.61
HSD17B10 Q99714 1/20 0.61
ADRA2B P18089 1/20 0.54
PTGS1 P23219 1/20 0.54
HTT P42858 1/20 0.50
APP P05067 3/20 0.48
POLB P06746 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
GAA P10253 2/20 0.43
IDO1 P14902 1/20 0.42
MEN1 O00255 1/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.42
KMT2A Q03164 1/20 0.42
NFE2L2 Q16236 1/20 0.41
EP300 Q09472 1/20 0.41
KAT8 Q9H7Z6 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6598910 0.98 ALDH1A1 (0.61) ALDH1A1CYP3A4TDP1TSHRHSD17B10
SCHEMBL1341474 0.85 ALDH1A1 (0.53) ALDH1A1CYP3A4TDP1TSHRHSD17B10
SCHEMBL28509155 0.84 ALDH1A1 (0.77) ALDH1A1CYP3A4TDP1TSHRHSD17B10
SCHEMBL112310 0.82 ALDH1A1 (0.59) ALDH1A1CYP3A4TDP1TSHRHSD17B10
SCHEMBL29937119 0.82 ALDH1A1 (0.59) ALDH1A1CYP3A4TDP1TSHRHSD17B10
SCHEMBL31521994 0.81 ALDH1A1 (0.61) ALDH1A1CYP3A4TDP1TSHRHSD17B10
SCHEMBL1341491 0.80 NFE2L2 (0.46) ALDH1A1CYP3A4TDP1TSHRHSD17B10
Hydrochloric Acid SCHEMBL27462411 0.80 ALDH1A1 (0.61) ALDH1A1CYP3A4TDP1TSHRHSD17B10
SCHEMBL15624568 0.79 SLC9A1 (0.48) ALDH1A1CYP3A4TDP1TSHRHSD17B10
SCHEMBL1341120 0.79 ALDH1A1 (0.57) ALDH1A1CYP3A4TDP1TSHRADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 560 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118724731-B Two-step preparation method of 4-fluoro-2-methoxy-5-nitroaniline 山东仁一生物科技有限责任公司 2024-10-29 CN claimed
CN-118724731-A Two-step preparation method of 4-fluoro-2-methoxy-5-nitroaniline 山东仁一生物科技有限责任公司 2024-10-01 CN claimed
CN-118439975-A Preparation method of 4-fluoro-2-methoxy-5-nitro-N-tert-butoxyaniline 川北医学院 2024-08-06 CN claimed
CN-116199569-A Preparation method of antitumor drug Lin Zage key phenol intermediate 浙江科聚生物医药有限公司 2023-06-02 CN claimed
CN-112409192-A Purification method of 4-fluoro-2-methoxyaniline 启东东岳药业有限公司 2021-02-26 CN claimed
EP-4743465-A1 BICYCLIC MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. Hoffmann-La Roche AG (CH) 2026-05-20 EP disclosed
EP-4739670-A1 MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. Hoffmann-La Roche AG (CH) 2026-05-13 EP disclosed
US-12600711-B2 Triazacyclododecansulfonamide (TCD)-based protein secretion inhibitors KEZAR LIFE SCIENCES, INC. (US) 2026-04-14 US disclosed
EP-4720060-A1 PRMT5 INHIBITORS Ryvu Therapeutics S.A. (PL) 2026-04-08 EP disclosed
US-12528802-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2026-01-20 US disclosed
US-12503440-B2 Nitroxoline derivative, preparation method therefor, and use thereof Jiangsu Yahong Meditech Co. (CN) 2025-12-23 US disclosed
US-20250353848-A1 HETEROCYCLIC PAD4 INHIBITORS CELGENE CORPORATION 2025-11-20 US disclosed
CN-1076195-A N-Benzoylbenzene sulfonamide derivatives GLAXO GROUP LTD (GB) 1993-09-15 CN disclosed
CN-1073430-A Benzanilide derivatives GLAXO GROUP LTD (GB) 1993-06-23 CN disclosed
CN-1071919-A N-Benzoylbenzene sulfonamide derivatives GLAXO GROUP LTD (GB) 1993-05-12 CN disclosed
WO-1993006084-A1 BENZANILIDE DERIVATIVES AS 5-HT1D ANTAGONISTS GLAXO GROUP LIMITED (GB) 1993-04-01 WO disclosed
EP-0533267-A1 Benzanilide derivatives as 5-HT1D antagonists GLAXO GROUP LIMITED (GB) 1993-03-24 EP disclosed
EP-0533268-A1 Benzanilide derivatives as 5-HT1D antagonists GLAXO GROUP LIMITED (GB) 1993-03-24 EP disclosed
EP-0485157-A2 Esters and amides of substituted pyrrole acetic acids FGN, INC. (US) 1992-05-13 EP disclosed
US-4044049-A Phenyl benzoic acid compounds MERCK & CO., INC. (US) 1977-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250353848-A1 HETEROCYCLIC PAD4 INHIBITORS PADI4, PADI1, PADI6 ALDH1A1 163/4885CYP3A4 273/4885TDP1 8/4885
US-12503440-B2 Nitroxoline derivative, preparation method therefor, and use thereof NOS1, NQO1, NOS2 ALDH1A1 752/4885CYP3A4 120/4885TDP1 1968/4885
US-12528802-B2 Heterocyclic compound GBA2, GBA1, GALC ALDH1A1 2563/4885CYP3A4 4702/4885TDP1 1860/4885
US-12600711-B2 Triazacyclododecansulfonamide (TCD)-based protein secretion inhibitors CD274, CD40, ICOS ALDH1A1 4237/4885CYP3A4 3166/4885TDP1 3560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.