Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL18729662 | 1.00 | — | — | |
| Tetrahydrofuran SCHEMBL22230565 | 1.00 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL1005228 | 0.95 | ALDH1A1 (0.89) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL1450115 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL22129675 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL732690 | 0.90 | — | — | |
| Tetrahydrofuran SCHEMBL6345343 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL267714 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL4444183 | 0.90 | ALDH1A1 (0.80) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL4076453 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534847-B2 | Copolymers of ethylene with α-olefins | BASELL POLYOLEFINE GMBH (DE) | 2009-05-19 | — | — | US | disclosed |
| WO-2008004986-A1 | CATALYST SYSTEM FOR OLIGOMERIZATION OF OLEFINS | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2008-01-10 | — | — | WO | disclosed |
| US-20050282979-A1 | Copolymers of ethylene with alpha-olefins | BASELL POLYOLEFINE GMBH (DE) | 2005-12-22 | — | — | US | disclosed |