Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA6 | P23280 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28242100 | 0.84 | MAOA (0.53) | TDP1ALDH1A1KDM4EMAPTSRD5A2 | |
| SCHEMBL31233564 | 0.78 | SRD5A2 (0.47) | ALDH1A1KDM4EMAPTSRD5A2SRD5A1 | |
| SCHEMBL29238410 | 0.76 | ALDH1A1 (0.40) | TDP1ALDH1A1KDM4EMAPTSRD5A2 | |
| SCHEMBL4564236 | 0.76 | OPRM1 (0.37) | ALDH1A1KDM4EMAPTSMN1; SMN2TP53 | |
| SCHEMBL9757529 | 0.73 | CHRNB2 (0.50) | ALDH1A1HSD17B10CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL384702 | 0.73 | KDM1A (0.38) | TDP1ALDH1A1KDM4EPOLBKDM1A | |
| SCHEMBL13460942 | 0.73 | CHRNB2 (0.39) | KDM4EHSD17B10TSHR | |
| SCHEMBL6671284 | 0.72 | PNMT (0.56) | KDM1A | |
| SCHEMBL20526162 | 0.72 | HTR2C (0.41) | KDM4ESRD5A1HSD17B10CA1CA2 | |
| SCHEMBL29396876 | 0.72 | PNMT (0.56) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108570059-A | A kind of compound and its preparation and application with PRMT5 inhibitory activity | 中国科学院上海药物研究所 | 2018-09-25 | — | — | CN | disclosed |
| EP-2132193-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | Boehringer Ingelheim International GmbH (DE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008116881-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-02 | — | — | WO | disclosed |