SCHEMBL456773

SCHEMBL456773

CCCc1[c]c(Cl)c(-c2ccccc2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.35
CSNK2A1 P68400 2/20 0.34
ADORA3 P0DMS8 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
CTRC Q99895 2/20 0.33
ALDH1A1 P00352 3/20 0.31
HPGD P15428 3/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
HSD17B10 Q99714 2/20 0.31
KDM4E B2RXH2 2/20 0.31
ADRB2 P07550 1/20 0.31
NPC1 O15118 1/20 0.31
MAPT P10636 1/20 0.31
PKM P14618 1/20 0.31
RAB9A P51151 1/20 0.31
HTR7 P34969 1/20 0.30
PSMB5 P28074 1/20 0.30
ESR2 Q92731 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL455996 0.86 CYP2A6 (0.38) CYP2A6CSNK2A1ADORA3ADORA2AADORA1
SCHEMBL458760 0.81 ESR2 (0.34) CYP2A6ADORA3ADORA2AADORA1ALDH1A1
SCHEMBL457803 0.79 ADORA3 (0.33) CSNK2A1ADORA3ADORA2AADORA1ALDH1A1
SCHEMBL457437 0.79 ADORA3 (0.33) ADORA3ADORA2AADORA1ALDH1A1HPGD
SCHEMBL457181 0.77 ADRB2 (0.33) ADORA3ADORA2AADORA1ALDH1A1ADRB2
SCHEMBL12503755 0.72 CYP2A6 (0.41) CYP2A6CSNK2A1CTRCALDH1A1HPGD
SCHEMBL456350 0.71 CYP2A6 (0.44) CYP2A6CSNK2A1CTRCALDH1A1HPGD
SCHEMBL4155256 0.71 PSMB5 (0.38) PSMB5
SCHEMBL10886368 0.71 CNR1 (0.38) HSD17B10NPC1RAB9A
SCHEMBL455577 0.68 ALDH1A1 (0.41) CYP2A6CSNK2A1CTRCALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2614053-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-07-17 EP disclosed
WO-2012033225-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-03-15 WO disclosed