Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456470 | 0.89 | TP53 (0.34) | ADORA3ADORA2AADORA1SMN1; SMN2ADRB2 | |
| SCHEMBL458760 | 0.81 | ESR2 (0.34) | ADORA3ADORA2AADORA1SMN1; SMN2ADRB2 | |
| SCHEMBL456773 | 0.79 | CYP2A6 (0.35) | ADORA3ADORA2AADORA1SMN1; SMN2ADRB2 | |
| SCHEMBL457803 | 0.79 | ADORA3 (0.33) | ADORA3ADORA2AADORA1SMN1; SMN2ADRB2 | |
| SCHEMBL457181 | 0.77 | ADRB2 (0.33) | ADORA3ADORA2AADORA1ADRB2ALDH1A1 | |
| SCHEMBL456112 | 0.77 | ESR2 (0.36) | ADORA3ADORA2AADORA1SMN1; SMN2ADRB2 | |
| SCHEMBL456752 | 0.75 | CYP2A6 (0.38) | ADORA3ADORA2AADORA1TP53HTR7 | |
| SCHEMBL456618 | 0.75 | ALDH1A1 (0.38) | ADORA3ADORA2AADORA1SMN1; SMN2ADRB2 | |
| SCHEMBL2235575 | 0.71 | USP7 (0.33) | SMN1; SMN2ALDH1A1HPGDTP53 | |
| SCHEMBL457978 | 0.71 | TP53 (0.32) | ADORA3ADORA2AADORA1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |