SCHEMBL4570267

SCHEMBL4570267

NC1=NC2NC=NC2C(=O)N1

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
HBB P68871 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GSK3B P49841 1/20 0.30
BACE1 P56817 1/20 0.30
STING1 Q86WV6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4750893 0.67 ALDH1A1 (0.32) ALDH1A1LMNATP53HPGDALOX15
SCHEMBL15045875 0.66 STING1 (0.42) ALDH1A1LMNATP53HPGDALOX15
SCHEMBL14001854 0.65 STING1 (0.41) STING1
SCHEMBL16203318 0.64 GSK3B (0.31) GSK3BBACE1
SCHEMBL12958962 0.64
SCHEMBL18870640 0.63 STING1 (0.36) STING1
SCHEMBL14076163 0.63 BACE1 (0.44) BACE1
SCHEMBL17928575 0.61 STING1 (0.32) STING1
SCHEMBL14818148 0.61
SCHEMBL15257768 0.61 PDE2A (0.44) STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3543238-A1 NUCLEOSIDE DERIVATIVE HAVING PHYSICAL ACTIVITIES INCLUDING ANTI-VIRAL ACTIVITY National Center for Global Health and Medicine (JP) 2019-09-25 EP disclosed
US-10196344-B2 Glaucocalyxin a derivative and preparation method and application thereof SUZHOU PHARMAVAN CANCER RESEARCH CENTER CO., LTD. (CN) 2019-02-05 US disclosed
WO-2016138461-A1 WATER SOLUBLE FLUORESCENT OR COLORED DYES COMPRISING CONJUGATING GROUPS SONY CORPORATION (JP) 2016-09-01 WO disclosed
US-8287939-B2 Method for manufacturing substrate for biochip AZBIL CORPORATION (JP) 2012-10-16 US disclosed
US-20120122819-A1 GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS SOCPRA - SCIENCES ET GENIE S.E.C. (CA) 2012-05-17 US disclosed
US-20120122819-A1 GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS SOCPRA - SCIENCES ET GENIE S.E.C. (CA) 2012-05-17 US disclosed
US-20100288727-A1 METHOD FOR MANUFACTURING SUBSTRATE FOR BIOCHIP YAMATAKE CORPORATION (JP) 2010-11-18 US disclosed
US-7807105-B2 Substrate for biochip YAMATAKE CORPORATION (JP) 2010-10-05 US disclosed
US-20080253928-A1 Substrate surface capable of reacting with biological substances and having a region not reacting with the biological substances;sunken bottomed wells formed in the surface; and a layer capable of reacting with the biological substances having a surface exposed only at the bottoms of the bottomed wells YAMATAKE CORPORATION (JP) 2008-10-16 US disclosed
EP-1939621-A1 SUBSTRATE FOR BIOCHIP, BIOCHIP, METHOD FOR MANUFACTURING SUBSTRATE FOR BIOCHIP, AND METHOD FOR MANUFACTURING BIOCHIP Yamatake Corporation (JP) 2008-07-02 EP disclosed
US-20070135436-A1 Chemical compounds CLAVIS PHARMA AS (NO) 2007-06-14 US disclosed
US-20070135436-A1 Chemical compounds CLAVIS PHARMA AS (NO) 2007-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10196344-B2 Glaucocalyxin a derivative and preparation method and application thereof SSB, GYPA, PEX14 ALDH1A1 4846/4885LMNA 199/4885TP53 2023/4885
US-20070135436-A1 Chemical compounds FASN, ALOX5, ALOX15 ALDH1A1 88/4885LMNA 201/4885TP53 1838/4885
US-20120122819-A1 GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS GDA, RNMT, GNPDA1 ALDH1A1 1272/4885LMNA 3267/4885TP53 1184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.