Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24724891 | 1.00 | DPP4 (0.47) | DPP4SLC6A3TP53CA12CA1 | |
| SCHEMBL22143669 | 1.00 | DPP4 (0.47) | DPP4SLC6A3TP53CA12CA1 | |
| SCHEMBL8283254 | 1.00 | DPP4 (0.47) | DPP4SLC6A3TP53CA12CA1 | |
| SCHEMBL2608454 | 1.00 | DPP4 (0.47) | DPP4SLC6A3TP53CA12CA1 | |
| SCHEMBL954821 | 1.00 | DPP4 (0.47) | DPP4SLC6A3TP53CA12CA1 | |
| Hydrochloric Acid SCHEMBL954820 | 0.98 | DPP4 (0.46) | DPP4SLC6A3TP53CA12CA1 | |
| Hydrochloric Acid SCHEMBL1069570 | 0.98 | DPP4 (0.46) | DPP4SLC6A3TP53CA12CA1 | |
| Hydrochloric Acid SCHEMBL20588914 | 0.98 | DPP4 (0.46) | DPP4SLC6A3TP53CA12CA1 | |
| Hydrochloric Acid SCHEMBL3642646 | 0.98 | DPP4 (0.46) | DPP4SLC6A3TP53CA12CA1 | |
| SCHEMBL8254579 | 0.98 | SLC6A3 (0.45) | DPP4SLC6A3TP53CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200283435-A1 | Autotaxin Inhibitory Compunds | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2020-09-10 | — | — | US | disclosed |
| US-10654846-B2 | Autotaxin inhibitory compounds | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2020-05-19 | — | — | US | disclosed |
| US-20180016274-A1 | AUTOTAXIN INHIBITORY COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-01-18 | — | — | US | disclosed |
| US-20180016274-A1 | AUTOTAXIN INHIBITORY COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-01-18 | — | — | US | disclosed |
| WO-2016124939-A1 | AUTOTAXIN INHIBITORY COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-08-11 | — | — | WO | disclosed |
| CN-102753166-B | Tetrapeptide analogs, preparation method and use thereof | SHANGHAI ALLIST PHARMACEUTICALS, INC. (CN) | 2014-10-15 | — | — | CN | disclosed |
| US-8377949-B2 | Quinazolinedione chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-02-19 | — | — | US | disclosed |
| US-8377949-B2 | Quinazolinedione chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-02-19 | — | — | US | disclosed |
| EP-2188277-B1 | QUINAZOLINEDIONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-11-21 | — | — | EP | disclosed |
| US-20120122863-A1 | Quinazolinedione Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-17 | — | — | US | disclosed |
| US-20120122863-A1 | Quinazolinedione Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-17 | — | — | US | disclosed |
| US-7795245-B2 | Heterobicyclic metalloprotease inhibitors | Atlantos Pharmaceuticals Holding, Inc. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090137547-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2009-05-28 | — | — | US | disclosed |
| WO-2009023655-A1 | QUINAZOLINEDIONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-02-19 | — | — | WO | disclosed |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS, INC. | 2007-07-05 | — | — | US | disclosed |
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122863-A1 | Quinazolinedione Chymase Inhibitors | CMA1, CTSC, TPSG1 | DPP4 6/4885SLC6A3 2147/4885TP53 2179/4885 |
| US-10654846-B2 | Autotaxin inhibitory compounds | ENPP2, RNASE1, ATXN10 | DPP4 1830/4885SLC6A3 3322/4885TP53 900/4885 |
| US-20200283435-A1 | Autotaxin Inhibitory Compunds | ENPP2, RNASE1, ATXN10 | DPP4 2147/4885SLC6A3 3537/4885TP53 983/4885 |
| US-20090137547-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, TIMP3, MMP3 | DPP4 139/4885SLC6A3 1609/4885TP53 3627/4885 |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, TIMP3, MMP3 | DPP4 139/4885SLC6A3 1609/4885TP53 3627/4885 |
| US-20180016274-A1 | AUTOTAXIN INHIBITORY COMPOUNDS | ENPP2, RNASE1, ATXN10 | DPP4 1830/4885SLC6A3 3322/4885TP53 900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.