Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071681 | 0.80 | MPO (0.60) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL11195911 | 0.76 | LMNA (0.55) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL18901361 | 0.76 | LMNA (0.55) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL597128 | 0.76 | LMNA (0.55) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL30383094 | 0.76 | LMNA (0.55) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL6819 | 0.76 | TAAR1 (0.63) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL6896647 | 0.76 | LMNA (0.55) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL540771 | 0.76 | LMNA (0.55) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4886061 | 0.74 | LMNA (0.53) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5074839 | 0.74 | LMNA (0.53) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10744127-B2 | MDR-reversing 8-hydroxy-quinoline derivatives | MAGYAR TUDOMÁNYOS AKADÉMIA TERMÉSZETTUDOMÁNYI KUTATÓKÖZPONT (HU) | 2020-08-18 | — | — | US | claimed |
| US-20190151306-A1 | MDR-REVERSING 8-HYDROXY-QUINOLINE DERIVATIVES | MAGYAR TUDOMÁNYOS AKADÉMIA TERMÉSZETTUDOMÁNYI KUTATÓKÖZPONT (HU) | 2019-05-23 | — | — | US | claimed |
| EP-3440070-A2 | MDR-REVERSING 8-HYDROXY-QUINOLINE DERIVATIVES | Magyar Tudományos Akadémia Természettudományi Kutatóközpont (HU) | 2019-02-13 | — | — | EP | claimed |
| WO-2017175018-A2 | MDR-REVERSING 8-HYDROXY-QUINOLINE DERIVATIVES | MAGYAR TUDOMÁNYOS AKADÉMIA TERMÉSZETTUDOMÁNYI KUTATÓKÖZPONT (HU) | 2017-10-12 | — | — | WO | claimed |
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | claimed |
| WO-2008100618-A2 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | claimed |
| EP-3440070-A2 | MDR-REVERSING 8-HYDROXY-QUINOLINE DERIVATIVES | Magyar Tudományos Akadémia Természettudományi Kutatóközpont (HU) | 2019-02-13 | — | — | EP | disclosed |
| WO-2017175018-A2 | MDR-REVERSING 8-HYDROXY-QUINOLINE DERIVATIVES | MAGYAR TUDOMÁNYOS AKADÉMIA TERMÉSZETTUDOMÁNYI KUTATÓKÖZPONT (HU) | 2017-10-12 | — | — | WO | disclosed |
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
| WO-2008100618-A2 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151306-A1 | MDR-REVERSING 8-HYDROXY-QUINOLINE DERIVATIVES | ABCC1, ABCB1, ABCC8 | LMNA 2388/4885KMT2A 800/4885MEN1 3784/4885 |
| US-10744127-B2 | MDR-reversing 8-hydroxy-quinoline derivatives | ABCC1, ABCB1, ABCC8 | LMNA 2388/4885KMT2A 800/4885MEN1 3784/4885 |
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | CTSS, CTSK, CTSZ | LMNA 3515/4885KMT2A 4390/4885MEN1 4836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.