Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 18/20 | 0.43 |
| ▸ | WNT1 | P04628 | 7/20 | 0.43 |
| ▸ | CLK2 | P49760 | 4/20 | 0.43 |
| ▸ | CLK3 | P49761 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 6/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27980243 | 0.71 | ULK1 (0.45) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL28079206 | 0.70 | DYRK1A (0.69) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL5658987 | 0.70 | DYRK1A (0.40) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL3602706 | 0.67 | DYRK1A (0.46) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL6135719 | 0.67 | OPRK1 (0.30) | — | |
| SCHEMBL4593853 | 0.66 | ROCK2 (0.43) | DYRK1A | |
| SCHEMBL28079290 | 0.66 | PRKAG1 (0.48) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL28087969 | 0.65 | CLK2 (0.47) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL13554360 | 0.65 | JAK2 (0.50) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL28258471 | 0.65 | NTRK1 (0.43) | DYRK1AWNT1CLK2CLK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689493-A4 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1689493-A1 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Pharma Company (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005065779-A1 | CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |