SCHEMBL4594492

SCHEMBL4594492

CC(=O)c1cccc(N2C(=O)C=CC2=O)c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 10/20 0.62
FAAH O00519 4/20 0.62
HSP90AA1 P07900 3/20 0.58
LMNA P02545 1/20 0.54
TSHR P16473 1/20 0.52
POLB P06746 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
ALDH1A1 P00352 2/20 0.51
PKM P14618 2/20 0.51
HTT P42858 2/20 0.51
ATM Q13315 1/20 0.51
MAPT P10636 2/20 0.51
MEN1 O00255 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
KMT2A Q03164 1/20 0.51
APOBEC3G Q9HC16 1/20 0.51
PARP1 P09874 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29510515 1.00 MGLL (0.62) MGLLFAAHHSP90AA1LMNATSHR
SCHEMBL8530013 0.85 MGLL (0.67) MGLLFAAHHSP90AA1TDP1ALDH1A1
SCHEMBL10886262 0.84 MGLL (0.60) MGLLFAAHHSP90AA1ALDH1A1PKM
SCHEMBL32670837 0.84 NSD2 (0.67) MGLLFAAHHSP90AA1POLBTDP1
SCHEMBL29510746 0.84 PARP1 (0.65) MGLLFAAHHSP90AA1LMNAALDH1A1
SCHEMBL11023896 0.84 MGLL (0.64) MGLLFAAHHSP90AA1ALDH1A1PKM
SCHEMBL10515423 0.84 PARP1 (0.65) MGLLFAAHHSP90AA1LMNAALDH1A1
SCHEMBL522308 0.84 NSD2 (0.67) MGLLFAAHHSP90AA1POLBTDP1
SCHEMBL10882516 0.83 MGLL (0.58) MGLLFAAHHSP90AA1ALDH1A1PKM
SCHEMBL24529797 0.82 MGLL (0.62) MGLLFAAHHSP90AA1ALDH1A1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114432301-B Covalent inhibitor derivative and application thereof in treatment of viral infection 北京大学 2024-05-31 CN disclosed
US-11564971-B2 Hyaluronic acid derivative having amino acid and steryl group introduced thereinto CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-01-31 US disclosed
WO-2022160156-A1 LIGASE FUSION PROTEINS AND APPLICATIONS THEREOF GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD. (CN) 2022-08-04 WO disclosed
CN-114432301-A Covalent inhibitor derivative and application thereof in treating virus infection 北京大学 2022-05-06 CN disclosed
US-20200239598-A1 PRODUCTS AND METHODS FOR MONITORING ADHERENCE TO NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR THERAPY URSURE, INC. (US) 2020-07-30 US disclosed
US-20200123261-A1 NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF AVIDITY BIOSCIENCES LLC 2020-04-23 US disclosed
WO-2019075487-A1 PRODUCTS AND METHODS FOR MONITORING ADHERENCE TO NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR THERAPY URSURE, INC. HARVARD LIFE LAB (US) 2019-04-18 WO disclosed
EP-2682409-B1 DERIVATIVE OF HYALURONIC ACID MODIFIED WITH AMINO-CARBOXYLIC ACID CHUGAI PHARMACEUTICAL CO LTD (JP) 2017-07-05 EP disclosed
US-9598466-B2 Glycopeptide constructs and uses thereof SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2017-03-21 US disclosed
US-9493580-B2 Multivalent glycopeptide constructs and uses thereof SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2016-11-15 US disclosed
US-8846411-B2 Derivatives, reagents, and immunoassay for detecting levetiracetam MICROGENICS CORPORATION (US) 2014-09-30 US disclosed
US-20130095173-A1 MULTIVALENT GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2013-04-18 US disclosed
US-20110229510-A1 GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2011-09-22 US disclosed
US-20100317024-A1 DERIVATIVES, REAGENTS, AND IMMUNOASSAY FOR DETECTING LEVETIRACETAM MICROGENICS CORPORATION 2010-12-16 US disclosed
EP-1447099-B1 Antineoplastic polyethylene conjugates of cytostatic compounds and pharmaceuticals comprising same KRATZ FELIX (DE) 2008-01-09 EP disclosed
EP-1447099-A2 Antineoplastic polyethylene conjugates of cytostatic compounds and pharmaceuticals comprising same Kratz, Felix (DE) 2004-08-18 EP disclosed
EP-0934081-B1 ANTINEOPLASTIC CONJUGATES OF ALBUMIN KRATZ FELIX (DE) 2004-06-09 EP disclosed
US-6709679-B2 CONSISTING OF NATIVE OR THIOLATED TRANSFERRIN OR ALBUMIN OR OF POLYETHYLENE GLYCOL WITH ATLEAST ONE MERCAPTAN, HYDROXY OR AMINE GROUP AND CYTOSTATIC COMPOUNDS DERIVED THROUGH MALEINIMIDE OR HYDROXYSUCCINIMIDE ESTER COMPOUNDS KRATZ FELIX (DE) 2004-03-23 US disclosed
US-20020019343-A1 Antineoplastic conjugates of transferrin, albumin and polyethylene glycol KRATZ FELIX (DE) 2002-02-14 US disclosed
US-6310039-B1 TUMOR-INHIBITING CONJUGATES OF PROTEINS AND POLYMERS CONSISTING OF A SUITABLE CARRIER SYSTEM AND CYTOSTATIC COMPOUNDS KRATZ FELIX (DE) 2001-10-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200123261-A1 NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF POLM, POLN, POLI MGLL 4036/4885FAAH 4539/4885HSP90AA1 1136/4885
US-20130095173-A1 MULTIVALENT GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF B3GAT3, GOLGA2, FUT5 MGLL 439/4885FAAH 2540/4885HSP90AA1 1524/4885
US-20020019343-A1 Antineoplastic conjugates of transferrin, albumin and polyethylene glycol TFRC, ALB, FOLR1 MGLL 3432/4885FAAH 1010/4885HSP90AA1 286/4885
US-20200239598-A1 PRODUCTS AND METHODS FOR MONITORING ADHERENCE TO NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR THERAPY DNTT, POLRMT, SLC29A1 MGLL 3427/4885FAAH 3206/4885HSP90AA1 3981/4885
US-20100317024-A1 DERIVATIVES, REAGENTS, AND IMMUNOASSAY FOR DETECTING LEVETIRACETAM EPM2A, IGLV6-57, LAMTOR3 MGLL 828/4885FAAH 424/4885HSP90AA1 4705/4885
US-20110229510-A1 GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF B3GAT3, MICA, SIGLEC7 MGLL 2610/4885FAAH 4485/4885HSP90AA1 1142/4885
US-11564971-B2 Hyaluronic acid derivative having amino acid and steryl group introduced thereinto CD44, DAO, FUT6 MGLL 3283/4885FAAH 2169/4885HSP90AA1 214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.