Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 8/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597887 | 0.86 | CHRM3 (0.42) | CHRM3CHRM2CXCR3 | |
| SCHEMBL4597759 | 0.84 | KCNJ1 (0.51) | — | |
| SCHEMBL4597403 | 0.83 | CCR5 (0.52) | CHRM3CHRM2CXCR3CCR5 | |
| SCHEMBL4596041 | 0.74 | KDM4E (0.32) | CHRM3KMT2AMEN1 | |
| SCHEMBL4596620 | 0.71 | NPSR1 (0.38) | CHRM3CHRM2KMT2ACXCR3MEN1 | |
| SCHEMBL392531 | 0.70 | HRH3 (0.61) | KMT2AMEN1ATM | |
| SCHEMBL5576660 | 0.70 | CCR5 (0.68) | CHRM3CHRM2CCR5 | |
| SCHEMBL5576658 | 0.70 | CCR5 (0.68) | CHRM3CHRM2CCR5 | |
| SCHEMBL4597256 | 0.68 | DRD2 (0.34) | KMT2ACXCR3MEN1 | |
| SCHEMBL5181129 | 0.67 | CXCR3 (0.48) | CHRM3CHRM2CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |