Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | LITAF | Q99732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597825 | 0.84 | CHRM2 (0.39) | SLC6A4DPP4KCNH2DPP9HTR6 | |
| SCHEMBL5179386 | 0.76 | GRIN1 (0.38) | PKMHTR6 | |
| SCHEMBL4596366 | 0.75 | CHRM2 (0.37) | SLC6A4SLC6A3DPP4BACE1DPP9 | |
| SCHEMBL4596721 | 0.75 | CHRM2 (0.37) | SLC6A4SLC6A3DPP4BACE1DPP9 | |
| SCHEMBL4597529 | 0.75 | BACE1 (0.38) | SLC6A4SLC6A2SLC6A3DPP4BACE1 | |
| SCHEMBL4596506 | 0.72 | DRD2 (0.34) | SLC6A4SLC6A2SLC6A3DPP4BACE1 | |
| SCHEMBL4597256 | 0.72 | DRD2 (0.34) | SLC6A4SLC6A2SLC6A3DPP4BACE1 | |
| SCHEMBL4597579 | 0.71 | DRD2 (0.33) | SLC6A4SLC6A2SLC6A3DPP4DPP9 | |
| SCHEMBL4597871 | 0.71 | SLC6A2 (0.40) | SLC6A4SLC6A2SLC6A3DPP4KCNH2 | |
| SCHEMBL4598182 | 0.70 | GRIN1 (0.36) | SLC6A4SLC6A2SLC6A3PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |