SCHEMBL460030

SCHEMBL460030

COC(=O)CNc1ccccc1.CS(=O)(=O)O

nearest known ligand 0.49

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGTR1 known ✓ P30556 1/20 0.47
ALDH1A1 P00352 3/20 0.49
RAB9A P51151 3/20 0.49
LMNA P02545 2/20 0.49
MAPT P10636 2/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
NPC1 O15118 2/20 0.47
HPGD P15428 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
CA12 O43570 7/20 0.43
CA2 P00918 7/20 0.43
CA1 P00915 6/20 0.43
CA9 Q16790 6/20 0.43
CA14 Q9ULX7 3/20 0.43
PKM P14618 1/20 0.43
KEAP1 Q14145 1/20 0.42
CA7 P43166 2/20 0.42
PTPN2 P17706 1/20 0.42
PTPN1 P18031 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sulfuric Acid SCHEMBL5004844 0.96 ALDH1A1 (0.49) ALDH1A1RAB9ALMNAMAPTMEN1
SCHEMBL28161510 0.93 ALDH1A1 (0.47) ALDH1A1RAB9ALMNAMAPTMEN1
SCHEMBL658053 0.93 LMNA (0.54) ALDH1A1RAB9ALMNAMAPTMEN1
Hydrochloric Acid SCHEMBL76327 0.91 LMNA (0.53) ALDH1A1RAB9ALMNAMAPTMEN1
Benzene SCHEMBL28330086 0.91 LMNA (0.53) ALDH1A1RAB9ALMNAMAPTMEN1
Sulfur Dioxide SCHEMBL28176580 0.87 LMNA (0.50) ALDH1A1RAB9ALMNAMAPTMEN1
Hydrochloric Acid SCHEMBL8015558 0.84 MEN1 (0.48) ALDH1A1RAB9ALMNAMAPTMEN1
Nitric Acid SCHEMBL27965091 0.83 ALDH1A1 (0.47) ALDH1A1RAB9ALMNAMAPTMEN1
Cadaverine Tartrate SCHEMBL28296884 0.83 MAPT (0.47) ALDH1A1RAB9ALMNAMAPTMEN1
SCHEMBL11743349 0.83 POLB (0.47) ALDH1A1RAB9ALMNAMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2614066-B1 PROCESS FOR THE PRODUCTION OF CEPHALOSPORINS DSM SINOCHEM PHARM NL BV (NL) 2017-11-29 EP disclosed
EP-2367940-B1 Mutant penicillin G acylases DSM SINOCHEM PHARM NL BV (NL) 2017-11-22 EP disclosed
CN-106957236-A A kind of preparation method of Phenylglycine methyl ester methyl-hydrogen-sulfate monomethyl-sulfate salt 浙江昂利康制药股份有限公司 2017-07-18 CN disclosed
CN-103571907-B A kind of separation of enzymatic clarification cefaclor and purification process CHINA UNION CHEMPHARMA (SUZHOU) CO., LTD. (CN) 2016-01-13 CN disclosed
EP-1931619-B1 METHANESULPHONIC ACID SALT OF DIHYDROPHENYLGLYCINE METHYL ESTER OR OF PHENYLGLYCINE METHYL ESTER DSM SINOCHEM PHARM NL BV (NL) 2015-06-24 EP disclosed
CN-104628586-A PROCESS FOR ESTERIFICATION OF AN ORGANIC ACID DSM IP ASSETS BV 2015-05-20 CN disclosed
CN-103571907-A Separation and purification method for cefaclor by enzymatic synthesis CHINA UNION CHEMPHARMA SUZHOU CO LTD 2014-02-12 CN disclosed
US-8541199-B2 Mutant penicillin G acylases DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) 2013-09-24 US disclosed
EP-2614066-A1 PROCESS FOR THE PRODUCTION OF CEPHALOSPORINS DSM Sinochem Pharmaceuticals Netherlands B.V. (NL) 2013-07-17 EP disclosed
CN-103108879-A Process for the production of cephalosporins DSM SINOCHEM PHARM NL BV 2013-05-15 CN disclosed
WO-2012032040-A1 PROCESS FOR THE PRODUCTION OF CEPHALOSPORINS DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) 2012-03-15 WO disclosed
US-20110256585-A1 MUTANT PENICILLIN G ACYLASES DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) 2011-10-20 US disclosed
EP-2367940-A2 MUTANT PENICILLIN G ACYLASES DSM IP Assets B.V. (NL) 2011-09-28 EP disclosed
WO-2010072765-A2 MUTANT PENICILLIN G ACYLASES DSM IP ASSETS B.V. (NL) 2010-07-01 WO disclosed
US-20080249329-A1 Process For Esterification Of An Organic Acid DSM IP ASSETS B.V. (NL) 2008-10-09 US disclosed
CN-101277927-A Process for esterifying organic acids DSM IP ASSETS BV (NL) 2008-10-01 CN disclosed
EP-1931619-A2 PROCESS FOR ESTERIFICATION OF AN ORGANIC ACID DSMIP Assets B.V. (NL) 2008-06-18 EP disclosed
WO-2007039522-A2 PROCESS FOR ESTERIFICATION OF AN ORGANIC ACID DSM IP ASSETS B.V. (NL) 2007-04-12 WO disclosed