Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 6/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632006 | 0.88 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2 | |
| SCHEMBL4603597 | 0.82 | CTSL (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2 | |
| SCHEMBL4632097 | 0.78 | CTSK (0.45) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL4632101 | 0.78 | CTSK (0.45) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL10703068 | 0.77 | TAS1R3 (0.44) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL4632761 | 0.76 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2 | |
| SCHEMBL2455888 | 0.74 | PLA2G2A (0.55) | ALDH1A1MAPT | |
| SCHEMBL1068731 | 0.74 | PLA2G2A (0.55) | ALDH1A1MAPT | |
| SCHEMBL6824840 | 0.74 | PLA2G2A (0.55) | ALDH1A1MAPT | |
| SCHEMBL6828291 | 0.73 | CTSL (0.40) | SMN1; SMN2NPC1RAB9AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915351-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007011618-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |