Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24533723 | 0.91 | APP (0.61) | MAOBNR4A2RXRARXRBAPP | |
| SCHEMBL24533725 | 0.88 | F2 (0.53) | MAOBMAOARAB9ASMN1; SMN2NR4A2 | |
| SCHEMBL7989351 | 0.86 | LMNA (0.58) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL17024339 | 0.86 | LMNA (0.58) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL12601246 | 0.85 | ALOX5 (0.63) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL10013799 | 0.85 | LMNA (0.60) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL16016779 | 0.85 | LMNA (0.60) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL24533757 | 0.85 | APP (0.50) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL419050 | 0.85 | APP (0.69) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL5164170 | 0.84 | MEN1 (0.51) | LMNACYP1A2PTGS1SLC6A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447485-B2 | Class of bifunctional compounds with quanternary ammonium salt structure | BEIJING SHOWBY PHARMACEUTICAL CO., LTD. (CN) | 2022-09-20 | — | — | US | disclosed |
| CN-110087729-B | Bifunctional compound with quaternary ammonium salt structure | 北京硕佰医药科技有限责任公司 | 2022-04-05 | — | — | CN | disclosed |
| EP-3556435-B1 | CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE | BEIJING SHOWBY PHARMACEUTICAL CO LTD (CN) | 2020-10-28 | — | — | EP | disclosed |
| EP-3556435-A1 | CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE | Beijing Showby Pharmaceutical Co., Ltd. (CN) | 2019-10-23 | — | — | EP | disclosed |
| EP-0979819-B1 | Process for the production of substituted 3-hydroxypiperidines | SPEEDEL PHARMA AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| EP-0979824-B1 | Process for the preparation of substituted piperidine-epoxides | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | disclosed |
| CN-1161335-C | Method for preparing substituted piperidine | - | 2004-08-11 | — | — | CN | disclosed |
| CN-1111534-C | Method for preparing substituted piperidine-epoxide | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | CN | disclosed |
| US-6274735-B1 | RENIN INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| US-6268499-B1 | USEFUL AS RENIN INHIBITORS | HOFFMAN-LA ROCHE INC. | 2001-07-31 | — | — | US | disclosed |
| CN-1245800-A | Method for preparing substituted piperidine | HOFFMANN LA ROCHE (CH) | 2000-03-01 | — | — | CN | disclosed |
| CN-1245805-A | Method for preparing substituted piperidine-epoxide | HOFFMANN LA ROCHE (CH) | 2000-03-01 | — | — | CN | disclosed |
| EP-0979824-A1 | Process for the preparation of substituted piperidine-epoxides | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |
| EP-0979819-A1 | Process for the production of substituted 3-hydroxypiperidines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447485-B2 | Class of bifunctional compounds with quanternary ammonium salt structure | AGTR2, AGTR1, ADRB2 | LMNA 2541/4885CYP1A2 585/4885PTGS1 2581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.