Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16199733 | 0.83 | LOXL2 (0.46) | PTGS2ALDH1A1MAPTCYP3A4HTT | |
| SCHEMBL10796823 | 0.83 | TSHR (0.45) | PTGS2ALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL12777347 | 0.81 | NPBWR1 (0.40) | PTGS2ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL6947527 | 0.80 | TSHR (0.48) | ALDH1A1MAPTCYP3A4HTTNPSR1 | |
| SCHEMBL3903310 | 0.76 | ALDH1A1 (0.45) | ALDH1A1MAPTCYP3A4KDM4ENPSR1 | |
| SCHEMBL1225410 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTCYP3A4HTTHSD17B10 | |
| SCHEMBL9158 | 0.76 | ALDH1A1 (0.55) | ALDH1A1MAPTHTTNPSR1KMT2A | |
| SCHEMBL1983738 | 0.76 | VCAM1 (0.59) | ALDH1A1KDM4ETDP1POLB | |
| SCHEMBL2772403 | 0.76 | ALDH5A1 (0.59) | ALDH1A1MAPTKDM4EALOX15HSD17B10 | |
| SCHEMBL6410654 | 0.75 | ALDH1A1 (0.57) | ALDH1A1MAPTCYP3A4HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915341-A2 | COMPOUNDS AND COMPOSITIONS AS TPO MIMETICS | IRM, LLC (BM) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007022269-A2 | COMPOUNDS AND COMPOSITIONS AS TPO MIMETICS | IRM LLC (BM) | 2007-02-22 | — | — | WO | disclosed |