Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8366262 | 0.89 | KMT2A (0.70) | HDAC4KMT2AHDAC6MEN1EPHX1 | |
| SCHEMBL12426680 | 0.89 | HDAC4 (0.61) | HDAC4KMT2ATSHRHDAC6MEN1 | |
| SCHEMBL25401822 | 0.88 | HDAC4 (0.60) | HDAC4KMT2ATSHRHDAC6MEN1 | |
| SCHEMBL7532504 | 0.88 | HDAC4 (0.60) | HDAC4KMT2AHDAC6MEN1EPHX1 | |
| SCHEMBL17572994 | 0.88 | HDAC4 (0.60) | HDAC4KMT2ATSHRHDAC6MEN1 | |
| SCHEMBL13199301 | 0.87 | KDM4E (0.68) | HDAC4KMT2AMEN1EPHX1KDM4E | |
| SCHEMBL1424917 | 0.87 | KMT2A (0.66) | KMT2ATSHRUSP2MEN1MAPT | |
| SCHEMBL28457523 | 0.86 | ALDH1A1 (0.70) | HDAC4KMT2AMEN1EPHX1MAPT | |
| SCHEMBL27633457 | 0.86 | KMT2A (0.61) | HDAC4KMT2AMEN1ALDH1A1 | |
| SCHEMBL28975873 | 0.85 | HDAC4 (0.60) | HDAC4KMT2AHDAC6MEN1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008141057-A1 | DEUTERATED PIMAVANSERIN 1- (4-FLU0R0BENZYL) -3- (4-ISOBUTOXYBENZYL) -1- ( L-METHYL-PIPERIDIN-4-YL) -UREA | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008141057-A1 | DEUTERATED PIMAVANSERIN 1- (4-FLU0R0BENZYL) -3- (4-ISOBUTOXYBENZYL) -1- ( L-METHYL-PIPERIDIN-4-YL) -UREA | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
| US-20080280886-A1 | SUBSTITUTED UREAS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| US-20080280886-A1 | SUBSTITUTED UREAS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| US-20080280886-A1 | SUBSTITUTED UREAS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| US-20080234333-A1 | Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof | KANG JAE-HOON | 2008-09-25 | — | — | US | disclosed |
| EP-1915342-A1 | A NOVEL HYDROXAMIC ACID DERIVATIVE AS PEPTIDE DEFORMYLASE INHIBITOR AND MANUFACTURING METHOD THEREOF | Ildong Pharmaceutical Co., Ltd. (KR) | 2008-04-30 | — | — | EP | disclosed |
| WO-2006115353-A1 | A NOVEL HYDROXAMIC ACID DERIVATIVE AS PEPTIDE DEFORMYLASE INHIBITOR AND MANUFACTURING METHOD THEREOF | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234333-A1 | Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof | PDF, PEPD, DHPS | HDAC4 267/4885KMT2A 1445/4885TSHR 3586/4885 |
| US-20080280886-A1 | SUBSTITUTED UREAS | HTR4, HTR5A, HTR6 | HDAC4 1268/4885KMT2A 2286/4885TSHR 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.